Total Synthesis of Natural Dihydropyranones: A Contribution to the Structural Elucidation of Natural Products. Coibacins A and B, Cryptomoscatones D1, D2 and E3

Author(s): Ronaldo Aloise Pilli, Luiz Fernando Toneto Novaes, Vânia Maria Teixeira Carneiro, Roberta Lopes Drekener, Carolina Martins Avila.

Journal Name: Current Organic Synthesis

Volume 12 , Issue 5 , 2015

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Abstract:

Cryptomoscatones D1 and D2, dihydropyranones isolated from C. mandiocanna, had their stereochemistry solved after total syntheses and comparison of spectroscopic data of natural and synthetic samples. Natural dihydropyranones coibacins A and B, metabolites isolated from marine cyanobacterium cf. Oscillatoria sp, which display antileishmanial activity and anti-inflammatory properties, were synthesized and had their absolute configuration determined. Our efforts towards the synthesis of cryptomoscatone E3, natural dihydropyranone with unknown absolute configuration, are also discussed.

Keywords: Polyketides, Total Synthesis, Structural Elucidation, Coibacin, Cryptomoscatone.

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Article Details

VOLUME: 12
ISSUE: 5
Year: 2015
Page: [523 - 529]
Pages: 7
DOI: 10.2174/157017941205150821121851
Price: $58

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