This review deals with the important changes that have taken place in the last twenty to thirty years, on
the directions and objectives of organic synthesis. Target oriented synthesis now competes with diversity oriented
synthesis, and variations, in an attempt to occupy chemical space more completely. At the same time practicality,
efficiency, scalability and robustness are once again the major goals to be associated with atom, step and function
economies, within the context of sustainability.
Keywords: Continuous flow, diversity oriented synthesis, function oriented synthesis, new directions, practical
efficient synthesis, target oriented synthesis.
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