T-cell Activation Induces Dynamic Changes in miRNA Expression Patterns in CD4 and CD8 T-cell Subsets

Author(s): Nato Teteloshvili, Katarzyna Smigielska-Czepiel, Bart-Jan Kroesen, Elisabeth Brouwer, Joost Kluiver, Annemieke M. H. Boots, Anke van den Berg.

Journal Name: MicroRNA

Volume 4 , Issue 2 , 2015

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Abstract:

T-cell activation affects microRNA (miRNA) expression in T-cell subsets. However, little is known about the kinetics of miRNA regulation and possible differences between CD4 and CD8 T cells. In this study we set out to analyze the kinetics of activation-induced expression regulation of twelve pre-selected miRNAs. The dynamics of the expression of these miRNAs was studied in sorted CD4 and CD8 CD45RO- T cells of healthy individuals stimulated with

Keywords: Activation, antibodies, immune, microRNA, miRNA regulation, T cell.

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Article Details

VOLUME: 4
ISSUE: 2
Year: 2015
Page: [117 - 122]
Pages: 6
DOI: 10.2174/2211536604666150819194636
Price: $58

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