Title:T-cell Activation Induces Dynamic Changes in miRNA Expression Patterns in CD4 and CD8 T-cell Subsets
VOLUME: 4 ISSUE: 2
Author(s):Nato Teteloshvili, Katarzyna Smigielska-Czepiel, Bart-Jan Kroesen, Elisabeth Brouwer, Joost Kluiver, Annemieke M. H. Boots and Anke van den Berg
Affiliation:Department of Pathology & Medical Biology, University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
Keywords:Activation, antibodies, immune, microRNA, miRNA regulation, T cell.
Abstract:T-cell activation affects microRNA (miRNA) expression in T-cell subsets. However, little
is known about the kinetics of miRNA regulation and possible differences between CD4 and CD8 T
cells. In this study we set out to analyze the kinetics of activation-induced expression regulation of
twelve pre-selected miRNAs. The dynamics of the expression of these miRNAs was studied in sorted
CD4 and CD8 CD45RO- T cells of healthy individuals stimulated with
