The posttranslational modification or PTM is a later but subtle step in protein biosynthesis
via which to change the properties of a protein by adding a modified group to its one or more amino acid
residues. PTMs are responsible for many significant biological processes, and meanwhile for many
major diseases as well, such as cancer. Facing the avalanche of biological sequences generated in the
post-genomic age, it is important for both basic research and drug development to timely identify the
PTM sites in proteins. This Review is devoted to summarize the recent progresses in this area, with a focus on those predictors,
which were developed based on the pseudo amino acid composition or PseAAC approach, and for which a publicly
accessible web-server has been established. Meanwhile, the future challenge in this area has also been briefly addressed.
Keywords: Bi-Profile, Chou’s PseAAC, Hydroxylation, iHyd-PseAAC, iMethyl-PseAAC, iNitro-Tyr, iSNO-AAPair, iSNOPseAAC,
iUbis-Lys, methylation, nitrotyrosine, PSNO, PTM, S-nitrosylation, Ubiquitination.
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