An assembly of quinoline, triazole and oxime ether in a single molecular entity afforded a
new template that has been used for the generation of a small library of molecules as potential cytotoxic
agents. These molecules were synthesized successfully via a one pot multistep method using the copper(I)-catalyzed
[3+2]-azide-alkyne cycloaddition (CuAAC) in water as the key step. All these compounds were synthesized in good to
excellent yields and were screened for their inhibitory effects on the growth of four cancer cell lines in vitro. Some of
these compounds showed encouraging cytotoxic effects against lung cancer cells and inhibition of PDE4 in vitro.
Keywords: Quinoline, 1, 2, 3-triazole, oxime, cancer, PDE4.
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