Natural Naphthoquinones with Great Importance in Medicinal Chemistry

Author(s): Fernando de Carvalho da Silva, Vitor Francisco Ferreira.

Journal Name: Current Organic Synthesis

Volume 13 , Issue 3 , 2016

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Abstract:

This review involves the chemistry and biochemistry of lapachol, β-lapachone and lawsone, examples of bioactive natural products that still being under biological evaluation and stimulated several research groups to prepare derivatives and analogues and test them against several anticancer, trypanocidal, antinflammatory, tuberculostatic, and antimalarial targets, as well as other parasitology targets related to important infectious diseases.

Keywords: β-lapachone, lapachol, lawsone, derivatives, biological activities, synthesis.

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Article Details

VOLUME: 13
ISSUE: 3
Year: 2016
Page: [334 - 371]
Pages: 38
DOI: 10.2174/1570179412666150817220343
Price: $58

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