New thiazole and 1,3,4-thiadiazole derivatives were synthesized from the reaction of hydrazonoyl halides
and each of 3-(4-fluorophenyl)-3,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-2(1H)-carbothioamide
and (E)-3-[mercapto(phenylamino)methylene]-thiochroman-4-one, respectively. The structures of all the newly
synthesized compounds were established by elemental and spectral analyses. All of the synthesized compounds
were tested for anticancer activity against colon cancer cell line HT29, human breast cancer cells MCF-7 and human
hepatocellular carcinoma cell line HepG2. Many derivatives of the tested compounds showed moderate to high anticancer activity.
Also, molecular docking against HER2 kinase domain revealed high free binding energy and good binding mode. The structure activity
relationship (SAR) of tested compounds was studied.
Keywords: Carbothioamides, hydrazonoyl halides, benzosuberone, thiazoles, thiadiazoles, antitumor agents.
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