Around 40% of patients with breast cancer will present with a recurrence of the disease. Chemotherapy is
recommended for patients with recurrent hormone-independent or hormone-refractory breast cancer and almost all
patients with metastatic breast cancer (MBC) receive chemotherapy during their medical history. Nanoparticle albuminbound
(nab)-paclitaxel is a solvent-free, 130-nanometer particle formulation of paclitaxel. Nab-paclitaxel can be
administered to all patients for whom the treatment choice is a taxane. In this review, 6 patient profiles for which nabpaclitaxel
may be particularly useful are described and analyzed: (i) as first-line treatment of MBC, (ii) as second-line
treatment of MBC after oral chemotherapy, (iii) after a standard taxane, (iv) as third-line treatment after a standard taxane
and oral chemotherapy, (v) for patients with HER2-positive MBC and (vi) for patients with intolerance to standard
taxanes. Nab-paclitaxel is a rational treatment choice for patients with MBC in different settings, as well as for those with
prior exposure to a standard taxane.
Keywords: Capecitabine, chemotherapy, docetaxel, MBC, nab-paclitaxel, paclitaxel.
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