MicroRNA

Alberto Izzoti
Department of Health Sciences
University of Genoa
Via A. Pastore 1, I-16132
Genoa
Italy

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MicroRNAs and Physical Activity

Author(s): Valentina Altana, Marta Geretto, Alessandra Pulliero.

Abstract:

Micro-RNAs (miRNAs) are responsible for important and evolutionary-conserved regulatory functions in several cellular processes such as apoptosis, signalling, differentiation and proliferation. There is a growing interest in understanding more clearly the mechanisms regulating activation and suppression of miRNAs expression in benefit of health prevention advancement. It is now acknowledged that physical activity represents one of the most effective preventive agents in chronicdegenerative diseases. Indeed, a regular exercise exerts a great influence on several parameters and biological pathways, both at genomic and post-genomic levels. Recent works have highlighted the effects of structured physical activity on miRNAs modulation. Modulation of MiRNAs, regulated by exercise in human skeletal muscle, depends on type, duration and intensity of an exercise performed. The aim of this review is to provide a comprehensive overview of scientific evidence concerning the effects of physical activity on miRNAs and its relevance for chronic-degenerative diseases prevention.

Keywords: Endurance exercise, microRNA, myomiR, physical activity, resistance exercise, skeletal muscle.

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Article Details

VOLUME: 4
ISSUE: 2
Year: 2015
Page: [74 - 85]
Pages: 12
DOI: 10.2174/2211536604666150813152450
Price: $58