Metalloprotein Inhibitors for the Treatment of Human Diseases

Author(s): Yang Yang , Xue-Qin Hu , Qing-Shan Li , Xing-Xing Zhang , Ban-Feng Ruan , Jun Xu , Chenzhong Liao .

Journal Name: Current Topics in Medicinal Chemistry

Volume 16 , Issue 4 , 2016

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Abstract:

Metalloproteins have attracted momentous attentions for the treatment of many human diseases, including cancer, HIV, hypertension, etc. This article reviews the progresses that have been made in the field of drug development of metalloprotein inhibitors, putting emphasis on the targets of carbonic anhydrase, histone deacetylase, angiotensin converting enzyme, and HIV-1 integrase. Many other important metalloproteins are also briefly discussed. The binding and coordination modes of different marketed metalloprotein inhibitors are stated, providing insights to design novel metal binding groups and further novel inhibitors for metalloproteins.

Keywords: Chelating, Drug design, Drug development, Magnesium, Metalloprotein, Zinc.

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Article Details

VOLUME: 16
ISSUE: 4
Year: 2016
Page: [384 - 396]
Pages: 13
DOI: 10.2174/1568026615666150813145218
Price: $58

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