Multi-Target Strategy and Experimental Studies of Traditional Chinese Medicine for Alzheimer’s Disease Therapy

Author(s): Lin Li, Lan Zhang, Cui-cui Yang.

Journal Name: Current Topics in Medicinal Chemistry

Volume 16 , Issue 5 , 2016

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Abstract:

Alzheimer’s disease (AD) is a multifactorial complex disease. The pathogenesis of AD is very complicated, and involves the β-amyloid (Aβ) cascade, tau hyperphosphorylation, neuroinflammation, oxidative stress, mitochondrial dysfunction, reduced levels of neurotrophic factors, and damage and loss of synapses as well as cholinergic neurons. The multi-target characteristics of traditional Chinese medicine (TCM) may be advantageous over single-target drugs in the treatment of complex diseases. These drugs have therefore attracted more attention in the research and development of AD therapies. This review describes advances made in experimental studies of TCM for AD treatment. It discusses research, from our group and other laboratories, on TCM compound drugs (Shenwu capsule) and approximately 10 Chinese medicinal herb extracts (tetrahydroxystilbene glucoside, epimedium flavonoid, icariin, cornel iridoid glycoside, ginsenoside, puerarin, clausenamide, huperzine A, and timosaponins).

Keywords: Alzheimer's disease, Animal model, Compound drug, Herb extract, Multi-target, Therapy, Traditional Chinese medicine.

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Article Details

VOLUME: 16
ISSUE: 5
Year: 2016
Page: [537 - 548]
Pages: 12
DOI: 10.2174/1568026615666150813144003
Price: $58

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