Abstract
A simple, straightforward and eco-friendly protocol for the synthesis of pharmaceuticallyinteresting aryl/heteroaryl-substituted bis(6-aminouracil-5-yl)methane derivatives has been developed using sulfamic acid (NH2SO3H) as a cost-effective and non-toxic organo-catalyst via pseudomulticomponent reaction of 6-amino-1,3-dimethyluracil with aromatic/heteroaromatic aldehydes in aqueous ethanol at room temperature. Mild reaction conditions, good to excellent yields, ecofriendliness, easy isolation of products and avoidance of column chromatographic separation are some of the notable features of this protocol.
Keywords: Aqueous ethanol, bis(6-aminouracil-5-yl)methanes, eco-friendly, no column chromatography, room-temperature, sulfamic acid.
Current Organocatalysis
Title:Room Temperature Metal-Free Synthesis of Aryl/Heteroaryl-Substituted Bis(6-aminouracil-5-yl)methanes Using Sulfamic Acid (NH2SO3H) as an Efficient and Eco-friendly Organo-Catalyst
Volume: 3 Issue: 2
Author(s): Bubun Banerjee and Goutam Brahmachari
Affiliation:
Keywords: Aqueous ethanol, bis(6-aminouracil-5-yl)methanes, eco-friendly, no column chromatography, room-temperature, sulfamic acid.
Abstract: A simple, straightforward and eco-friendly protocol for the synthesis of pharmaceuticallyinteresting aryl/heteroaryl-substituted bis(6-aminouracil-5-yl)methane derivatives has been developed using sulfamic acid (NH2SO3H) as a cost-effective and non-toxic organo-catalyst via pseudomulticomponent reaction of 6-amino-1,3-dimethyluracil with aromatic/heteroaromatic aldehydes in aqueous ethanol at room temperature. Mild reaction conditions, good to excellent yields, ecofriendliness, easy isolation of products and avoidance of column chromatographic separation are some of the notable features of this protocol.
Export Options
About this article
Cite this article as:
Banerjee Bubun and Brahmachari Goutam, Room Temperature Metal-Free Synthesis of Aryl/Heteroaryl-Substituted Bis(6-aminouracil-5-yl)methanes Using Sulfamic Acid (NH2SO3H) as an Efficient and Eco-friendly Organo-Catalyst, Current Organocatalysis 2016; 3 (2) . https://dx.doi.org/10.2174/2213337202666150812231130
DOI https://dx.doi.org/10.2174/2213337202666150812231130 |
Print ISSN 2213-3372 |
Publisher Name Bentham Science Publisher |
Online ISSN 2213-3380 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Nuclear Factor Kappa B is a Promising Therapeutic Target in Inflammatory Lung Disease
Current Drug Targets Xenobiotic-Metabolizing Enzymes in Human Lung
Current Drug Metabolism Interaction of Small Molecules with Specific Immune Receptors: The p-i Concept and its Consequences
Current Immunology Reviews (Discontinued) Allergenic Tropomyosins and Their Cross-Reactivities
Protein & Peptide Letters Novel Therapeutic Approaches in Limiting Oxidative Stress and Inflammation
Current Pharmaceutical Biotechnology Multi-Component Synthesis of 6-Alkoxy-2-Amino-3,5-Dicyanopyridines
Letters in Organic Chemistry Solar Exfoliated Graphene Oxide: A Platform for Electrochemical Sensing of Epinephrine
Current Analytical Chemistry Recent Developments in Medicated Lozenges: A Promising Dosage Form for the Effective Delivery of Therapeutic Agents
Drug Delivery Letters Trends in the Exploration of Anticancer Targets and Strategies in Enhancing the Efficacy of Drug Targeting
Current Molecular Pharmacology Cosignaling Molecules Around LIGHT-HVEM-BTLA: From Immune Activation to Therapeutic Targeting
Current Molecular Medicine Withdrawal Notice: Pharmacological analysis of Cannabis sativa L.: A potent herbal plant
Mini-Reviews in Medicinal Chemistry Effect of Flavonoids on Human Health: Old Subjects but New Challenges
Recent Patents on Biotechnology Meet Our Editorial Board Member
Current Organic Synthesis Therapeutic Potential of Adipose-derived Stem Cells in the Treatment of Pulmonary Diseases
Current Stem Cell Research & Therapy Ligand-Based Homology Modeling as Attractive Tool to Inspect GPCR Structural Plasticity
Current Pharmaceutical Design Drug-Induced Phototoxicity; An Early In Vitro Identification of Phototoxic Potential of New Drug Entities in Drug Discovery and Development
Current Drug Safety Optimization of Site Targeted Zolmitriptan Delivery Using Polyox N12K and Methacrylic Acid
Current Drug Therapy The Mechanism of Adjuvanticity of Aluminium-Containing Formulas
Current Pharmaceutical Design Metabolic Profiling in Disease Diagnosis, Toxicology and Personalized Healthcare
Current Pharmaceutical Biotechnology Viral Bronchiolitis and Asthma Development: Lessons from Longitudinal Studies
Current Respiratory Medicine Reviews