Implants are an inevitable part of orthopaedic surgery. However, implant associated infection
remains a major challenge for orthopaedic surgeons and researchers. This review focuses on current
options available for prevention of implant associated infection, their drawbacks and future promising
applications of nanotechnology-based approaches. Nanobiotechnology has shown remarkable
progress in recent years especially in biomaterials, diagnostics, and drug delivery system. Although
several applications of nanobiotechnology in orthopaedics have been described, few have elaborated
their role in the prevention of implant related infection in orthopaedics. Novel “smart” drug delivery systems that release
antibiotics locally in response to stimuli such as pH, temperature, enzymes or antigens; implant surface modification on a
nanoscale to inhibit bacterial adhesion and propagation at the surgical site and biological approaches such as gene therapy
to neutralize bacterial virulence and biomolecules to inhibit the quorum sensing adhesion of bacteria and disruption of
biofilms can be used effectively to prevent orthopaedic implant related bacterial infection.
Keywords: Biological approaches, magnetic nanomaterial, nano coating, novel drug delivery system, Prevention of implant
associated infection, triggered release system.
Rights & PermissionsPrintExport