Emerging Strategies and Challenges for Controlled Delivery of Taxanes: A Comprehensive Review

Author(s): Mohit Mahajan, Rajneet Kaur Khurana, Nikhil Shri Sahajpal, Puneet Utreja, R. Sankar, Bhupinder Singh, Subheet Kumar Jain.

Journal Name: Current Drug Metabolism

Volume 16 , Issue 6 , 2015

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Abstract:

Taxanes introduction in the mid 90s leads to significant advancement as well as superlative improvement in the treatment of cancer. Since then, several strategies have been designed to enhance therapeutic potential of these agents by overcoming the limitations in drug delivery and pharmacokinetic constraints associated with conventional delivery. In this regard, controlled drug delivery systems for taxanes have contributed enormously by altering the pharmacokinetic profile, thus ultimately enhancing their therapeutic response. With their conferred stellar merits, controlled drug delivery systems have been able to surmount many of the challenges associated with conventional drug delivery systems. The altered absorption, resistance, low toxicity and cellular uptake profiles that lead to better safety from variegated carrier systems like nanocarriers, liposomes, solid lipid nanoparticles, nanoemulsions, nanocapsules, hydrogels and micelles for controlled delivery of taxanes call for an exhaustive review for future progressive work. Therefore, this review focuses on the altered pharmacokinetic, pharmacodynamic and toxicity patterns achieved from various controlled drug delivery approaches, with the latter half highlighting the clinical profile set ups and commercial aspects of controlled release drug delivery systems.

Keywords: Carrier approaches, conventional formulations, pharmacokinetics, resistance, targeted delivery, toxicity profile.

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Article Details

VOLUME: 16
ISSUE: 6
Year: 2015
Page: [453 - 473]
Pages: 21
DOI: 10.2174/1389200216666150812123414
Price: $58

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