Peptide Bacteriocins - Structure Activity Relationships

Author(s): Hashem Etayash, Sarfuddin Azmi, Ramana Dangeti, Kamaljit Kaur.

Journal Name: Current Topics in Medicinal Chemistry

Volume 16 , Issue 2 , 2016

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Abstract:

With the growing concerns in the scientific and health communities over increasing levels of antibiotic resistance, antimicrobial peptide bacteriocins have emerged as promising alternatives to conventional small molecule antibiotics. A substantial attention has recently focused on the utilization of bacteriocins in food preservation and health safety. Despite the fact that a large number of bacteriocins have been reported, only a few have been fully characterized and structurally elucidated. Since knowledge of the molecular structure is a key for understanding the mechanism of action and therapeutic effects of peptide, we centered our focus in this review on the structure-activity relationships of bacteriocins with a particular focus in seven bacteriocins, namely, nisin, microcin J25, microcin B17, microcin C, leucocin A, sakacin P, and pediocin PA-1. Significant structural changes responsible for the altered activity of the recent bacteriocin analogues are discussed here.

Keywords: Bacteriocin analogues, Bacteriocins, Structure-activity relationship.

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Article Details

VOLUME: 16
ISSUE: 2
Year: 2016
Page: [220 - 241]
Pages: 22
DOI: 10.2174/1568026615666150812121103
Price: $58

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