Nigella Sativa Improve Redox Homeostasis in Heart and Aorta of Diabetic Rat

Author(s): Abbasali Abbasnezhad, Saeed Niazmand, Maryam Mahmoudabady, Mohammad Soukhtanloo, Seyed Abdolrahim Rezaee, Seyed Mojtaba Mousavi.

Journal Name: Current Nutrition & Food Science

Volume 12 , Issue 1 , 2016

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Abstract:

Background: Oxidative stress plays a pivotal role in the development of diabetes complications. The present study investigated the effects of Nigella Sativa hydroalcholic extract on oxidative stress injuries of heart and aorta in streptozotocin- induced diabetic rats.

Methods: The animals were divided into six experimental groups; control, streptozotocin-diabetic, and diabetic rats treated with different doses of Nigella Sativa, 100, 200 and 400 mg/kg or metformin, 300 mg/kg, by daily gavage for 6 weeks. Malondialdehyde, total thiol levels and also the activities of Cu,Zn-superoxide dismutase and catalase in aortic and cardiac tissues were evaluated.

Results: The malondialdehyde levels were decreased in all treated groups compared to diabetic group (p < 0.05 to p < 0.001). Thiol levels were increased in cardiac tissues of metformin and 100 mg/kg Nigella sativa groups compared to diabetic group (p < 0.05, p < 0.001). The activity of Cu,Zn-superoxide dismutase in aortic tissues of 100 and 200 mg/kg Nigella sativa groups was higher than control and diabetic groups (p < 0.001) and those of cardiac tissues in 200 and 400 mg/kg Nigella sativa groups were higher than diabetic and control group (p < 0.05). The activity of catalase in cardiac tissues of metformin, 100 and 400 mg/kg Nigella sativa groups was reduced compared to diabetic group (p < 0.01).

Conclusion: The results showed that chronic administration of Nigella Sativa in streptozotocin-induced diabetic rats could decrease the oxidative stress in aortic and cardiac tissues.

Keywords: Diabetes mellitus, Nigella Sativa, oxidative stress, heart, aorta.

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Article Details

VOLUME: 12
ISSUE: 1
Year: 2016
Page: [35 - 41]
Pages: 7
DOI: 10.2174/1573401311666150804213742

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