Kainic acid and related members of kainoid family are amino acid-terpene hybrid natural products with
three stereocenters and promising bioactivities. Kainoids have been isolated from diverse marine and terrestrial organisms
and all of them feature a 3-carboxymethyl proline and C-4 side chain. The decorative molecular structure
and intriguing biological profile of kainic acid inspired the synthetic chemists in engineering the new protocol for
its asymmetric total syntheses. This article provides an account of research on kainic acid and few selective kainic
acid inspired molecules, including their isolation, total synthesis, biological and structure activity relationship
(SAR) studies. Particularly, the synthetic endeavours towards the building of kainic acid reported during the period
2012 till mid 2015 have been highlighted.
Keywords: Marine metabolites, synthesis, bioactivities, kainic acid, hybrid natural product.
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