Calothrixin A and B are pentacyclic alkaloids isolated from Calothrix Cyanobacteria with unique structural
features containing indolo[3,2-j]phenanthridine ring system. These alkaloids possess various biological activities
including growth inhibitory effects on a chloroquine-resistant strain of the malarial parasite Plasmodium falciparum
and activity against human cancer cells. In this review, various synthetic approaches developed so far for
calothrixin A & B and their bioactivities are described.
Keywords: Alkaloid, biogenesis, calothrixin, cyanobacteria, natural product, phenanthridine.
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