Recent Progress Towards the Total Synthesis and Biological Studies of Calothrixin A and B

Author(s): Prakash T. Parvatkar.

Journal Name: Current Organic Chemistry

Volume 20 , Issue 8 , 2016

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Abstract:

Calothrixin A and B are pentacyclic alkaloids isolated from Calothrix Cyanobacteria with unique structural features containing indolo[3,2-j]phenanthridine ring system. These alkaloids possess various biological activities including growth inhibitory effects on a chloroquine-resistant strain of the malarial parasite Plasmodium falciparum and activity against human cancer cells. In this review, various synthetic approaches developed so far for calothrixin A & B and their bioactivities are described.

Keywords: Alkaloid, biogenesis, calothrixin, cyanobacteria, natural product, phenanthridine.

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Article Details

VOLUME: 20
ISSUE: 8
Year: 2016
Page: [839 - 855]
Pages: 17
DOI: 10.2174/1385272819666150803235103
Price: $58

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