Tubercidin represents one of the most widely recognized nucleosides isolated from natural sources. The
major structural difference between adenosine and tubercidin is that one of the nitrogen atom is replaced by a C-H
group in the heterocyclic base. Tubercidin was first introduced into the clinic over 40 years ago. Since then, there
has been a steady interest and this review discusses the various approaches related to the synthesis of tubercidin
and its derivatives. The key aspects related to isolation, structure-activity relationships and biological activity are
Keywords: Tubercidin, natural product, nucleosides, antibiotic, synthesis.
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