Background: Anti-aging skin care is a growing popular topic in cosmetic and aesthetic fields, and skin care
rather then makeup tips draw more attention nowadays. The phenomenon of skin aging includes thinning of skin losses of
elasticity and moisture, pigmented spot formation, and wrinkle development. Along with growth in age, the decreased
rates of epithelium renewal and cellular recovery as well as the reduced contents of elastin, collagen, and glycosaminoglycans
all contribute to creases or folds of skin. Available strategies for wrinkle treatments include topical use of skin care
products with anti-aging contents, dermabrasion, laser, Botox injection, fillers injection, and facelift. Though all of these
above options can provide different degrees of improvement in facial wrinkles, the cost-effect, pain of intervention therapy,
and necessity of repetitive treatment may impact on choices made. Topical use of anti-aging skin products is the most
convenient and cheap way to achieve skin anti-aging effect. LycogenTM is an antioxidant, which can prevent the downregulation
of pro-collagen I, intracellular accumulation of malondialdehyde (MDA) and achieve the aim of skin rejuvenation.
Methods: Twenty-six female patients were included in our study with ages between 30 and 45. They were randomly
assigned to two groups: the vehicle control group and the experimental group. Patients in the control group applied a skin
care product without LycogenTMto the face via sonophoresis after facial cleanser use in the morning and at night. The experimental
group applied a LycogenTM -containing skin care product via sonophoresis in the same time schedule. We
evaluated results, including pigmented spots, wrinkles, texture, pores, and red area by VISIA on weeks 0, 1, 2, 4, 6, 8, and
10 respectively. Results: In the aspect of pigmented spots, the experimental group showed significant difference in comparison
with the vehicle control group on weeks 2, 6, 8, and 10. For wrinkles, the experimental group had better results on
weeks 1, 2, 4, 8, and 10. Measured by texture, the experimental group had better results on weeks 1, 2, 4, 6, 8, and 10. Determined
by pores, the experimental group had better results on weeks 2, 4, 6, 8, and 10. Concerning red areas, the experimental
group had better results on weeks 6, 8, and 10. (p < 0.05). Conclusion: In our study, we applied a LycogenTM-
containing product by sonophoresis as the experimental group in comparison with a skin care product without LycogenTM.
VISIA (Canfield Imaging Systems, Fairfield, NJ) was used to evaluate facial skin in aspects of pigmented spots, wrinkles,
texture, pores, and red area. Overall, LycogenTM had proven effectiveness on anti-oxidation as patients who used the Lycogen
TM -containing product had better outcomes.