Vitamin D and Cystic Fibrosis Lung Disease

Author(s): Ioanna Loukou , Barbara Boutopoulou , Sotirios Fouzas , Konstantinos Douros .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 15 , Issue 12 , 2015

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Abstract:

Vitamin D has been increasingly recognized as being involved in a wide spectrum of biological actions, including significant immunomodulatory effects. The cystic fibrosis (CF) airways are characterized by dysregulated and disproportionately increased, in relation to the underlying bacterial stimuli, inflammatory responses. Vitamin D downregulates pro-inflammatory cytokines and chemokines that promote tissue destruction, and which are abundant in CF lungs. However, despite mounting evidence for a pathophysiological role of Vitamin D in CF airways inflammation, there are only a few clinical reports supporting a relevance of Vitamin D insufficiency with CF airways damage, and so it is early to assign an indisputable causal role to Vitamin D. The present review will examine the current literature regarding the association of Vitamin D status with CF lung disease, and comment on the therapeutic implications accruing from these relations.

Keywords: Vitamin D, Cystic Fibrosis, Cystic Fibrosis Lung disease, Endobronchial Inflammation, Vitamin D Supplementation.

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Article Details

VOLUME: 15
ISSUE: 12
Year: 2015
Page: [974 - 983]
Pages: 10
DOI: 10.2174/138955751512150731111529
Price: $58

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