Data obtained through high-throughput technologies have gradually revealed that a unique stratified epithelial
architecture of human skin along with the antioxidant-response pathways provided vital defensive mechanisms against
UV radiation. However, it is noteworthy that skin is a major target for toxic insult by UV radiations that can alter its structure
and function. Substantial fraction of information has been added into the existing pool of knowledge related to natural
products mediated biological effects in UV exposed skin cells. Accumulating evidence has started to shed light on the potential
of these bioactive ingredients as protective natural products in cosmetics against UV photodamage by exerting biological
effects mainly through wide ranging intracellular signalling cascades of oxidative stress and modulation of miRNAs.
In this review, we have summarized recently emerging scientific evidences addressing underlying mechanisms of
UV induced oxidative stress and deregulation of signalling cascades and how natural products can be used tactfully to protect
against UV induced harmful effects.
Keywords: Natural products, UV, oxidative stress, DNA damage, DNA repair, protection, miRNA.
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