Flavonoids are secondary metabolites abundantly present in commonly consumed fruits and vegetables.
They possess diverse properties such as anti-inflammatory, anti-oxidant and anti-cancer. Epidemiologic
studies suggest that an enrich flavonoids diet is linked to a decreased risk of breast cancer. These protective
properties are due to the alteration of numerous signalling pathways involved in cancer-related phenomena
such as inflammation and proliferation. Human clinical trials examining the effect of supplementation
of some flavonoids on disease prevention have been conducted. There is no natural flavonoid that has
been approved for the treatment of breast cancer. However, natural flavonoids served as lead compounds in
the synthesis of cancer chemopreventive and/or therapeutic agents.
Keywords: Breast cancer, chemopreventive agents, chemotherapeutic agents, flavonoids.
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