Flavonoids, Breast Cancer Chemopreventive and/or Chemotherapeutic Agents

Author(s): Chantal Beatrice Magne Nde, Stephane Zingue, Evelyn Winter, Tania Beatriz Creczynski-Pasa, Thomas Michel, Xavier Fernandez, Dieudonne Njamen, Colin Clyne Hudson.

Journal Name: Current Medicinal Chemistry

Volume 22 , Issue 30 , 2015

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Abstract:

Flavonoids are secondary metabolites abundantly present in commonly consumed fruits and vegetables. They possess diverse properties such as anti-inflammatory, anti-oxidant and anti-cancer. Epidemiologic studies suggest that an enrich flavonoids diet is linked to a decreased risk of breast cancer. These protective properties are due to the alteration of numerous signalling pathways involved in cancer-related phenomena such as inflammation and proliferation. Human clinical trials examining the effect of supplementation of some flavonoids on disease prevention have been conducted. There is no natural flavonoid that has been approved for the treatment of breast cancer. However, natural flavonoids served as lead compounds in the synthesis of cancer chemopreventive and/or therapeutic agents.

Keywords: Breast cancer, chemopreventive agents, chemotherapeutic agents, flavonoids.

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Article Details

VOLUME: 22
ISSUE: 30
Year: 2015
Page: [3434 - 3446]
Pages: 13
DOI: 10.2174/0929867322666150729115321
Price: $58

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