The aim of the present study was to evaluate the effects of sodium butyrate on depressive-like behavior and mitochondrial
alteration parameters in animal models of depression induced by maternal deprivation or chronic mild stress
in Wistar rats. maternal deprivation was established by separating pups from their mothers for 3 h daily from postnatal
day 1 to day 10. Chronic mild stress was established by water deprivation, food deprivation, restraint stress, isolation and
flashing lights. Sodium butyrate or saline was administered twice a day for 7 days before the behavioral tests. Depressive
behavior was evaluated using the forced swim test. The activity of tricarboxylic acid cycle enzymes (succinate dehydrogenase
and malate dehydrogenase) and of mitochondrial chain complexes (I, II, II-III and IV) was measured in the striatum
of rats. From these analyses it can be observed that sodium butyrate reversed the depressive-like behavior observed in
both animal models of depression. Additionally, maternal deprivation and chronic mild stress inhibited mitochondrial respiratory
chain complexes and increased the activity of tricarboxylic acid cycle enzymes. Sodium butyrate treatment reversed
-maternal deprivation and chronic mild stress- induced dysfunction in the striatum of rats. In conclusion, sodium
butyrate showed antidepressant effects in maternal deprivation and chronic mild stress-treated rats, and this effect can be
attributed to its action on the neurochemical pathways related to depression.
Keywords: Major depression, Maternal deprivation, Chronic mild stress, Sodium butyrate, Mitochondria.
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