Proteins are the ultimate carriers of information encoded within genes. The salient feature
of proteins is their ability to perform a vast array of function with extraordinary specificity. This specificity
of proteins is related directly to their structural conformations, which arises as a result of complex
interactions among its constituent amino acid residues. Thus, analyzing proteins through these interactions
collectively is an extremely important, interesting and effective way to understand their dynamical
and structural properties. This review summarizes recent graph theoretical approaches in the
field of amino acid residue interaction networks (RIN), [also known as residue interaction graphs
(RIG), protein contact networks (PCN) or residue contact networks (RCN)] and the outcomes thereof.
It explains the strengths of network formalism in unraveling various aspects of the complex phenomena, upon which the
structure and function of proteins have a direct bearing.
Keywords: Allostery, amino acid residues, graph theory, protein contact networks, residue interaction networks, protein folding.
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