The last decade has witnessed a growing interest in natural and synthetic polysulfanes and their potential
uses in Medicine and Agriculture. Whilst the chemistry and biochemistry of these organic sulfur compounds is
slowly emerging and biological applications are being put into practice, their inorganic equivalents, the hydrogen
polysulfides, have attracted little attention so far. Recently, studies conducted in the field of hydrogen sulfide (H2S)
signaling have revealed a potential role of such simple sulfur molecules in the redox control of cysteine proteins
and associated, extensive cellular signaling. It is therefore worthwhile to consider more closely the chemistry of inorganic
polysulfides, their possible formation and occurrence in Biology and likely interactions with biologically
relevant functional groups and molecules. Here, a specific focus seems to be on thiol and disulfide groups in proteins
and enzymes of the cellular thiolstat.
Keywords: Cellular thiolstat, cysteine modification, hydrogen sulfide, polysulfide, redox modulation, signaling.
Rights & PermissionsPrintExport