ω-3 Polyunsaturated Fatty Acids Effects on the Cardiometabolic Syndrome and their Role in Cardiovascular Disease Prevention: An Update from the Recent Literature

Author(s): GianLuca Colussi, Cristiana Catena, Leonardo A. Sechi.

Journal Name: Recent Advances in Cardiovascular Drug Discovery (Discontinued)

Volume 9 , Issue 2 , 2014

Abstract:

Docosahexaenoic (DHA) and eicosapentaenoic (EPA) acid of the ω-3 family of polyunsaturated fatty acids (PUFA) are abundant in fatty fish and other marine sources. Their consistent consumption has been related to an improved cardiovascular risk especially in high risk patients and populations. In this review, we presented major findings about potential mechanisms of action and clinical evidence regarding ω-3 PUFA effect on the control and prevention of cardiovascular disease. This review is an update of our previous review (Colussi et al. Recent Pat Cardiovasc Drug Discov 2007;2:13-31) in which we additionally summarize and comment new literature of the past few years. Despite clinical studies have been significantly increased in the last years, the evidence in support of a beneficial role of ω-3 PUFA in cardiovascular prevention is still relatively weak. The growing improvement of medical interventions for cardiovascular prevention might explain why these molecules appear to have limited impact on the cardiovascular risk.

Keywords: Atherosclerosis, cardiovascular disease, cardiovascular prevention, cardiovascular risk factors, hypertriglyceridemia, hypertension, inflammation, ω-3 polyunsaturated fatty acids.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 9
ISSUE: 2
Year: 2014
Page: [78 - 96]
Pages: 19
DOI: 10.2174/1574890110666150724115111
Price: $58

Article Metrics

PDF: 23