Ophthalmic drug delivery system is very interesting and challenging due to the normal
physiologically factor of eyes which reduces the bioavailability of ocular products. The development
of new ophthalmic dosage forms for existing drugs to improve efficacy and bioavailability, patient
compliance and convenience has become one of the main trend in the pharmaceuticals industry. The present review
encompasses various conventional and novel ocular drug delivery systems, methods of preparation, characterization and
recent research in this area. Furthermore, the information on various commercially available in situ gel preparations and the
existing patents of in situ drug delivery systems i.e. in situ gel formation of pectin, in situ gel for therapeutic use, medical
uses of in situ formed gels and in situ gelling systems as sustained delivery for front of eye are also covered in this review.
Keywords: Formulation approaches, in situ gel, ophthalmic delivery, patents, polymers.
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