The exact mechanism by which nutritional deficiency and lysosomal enzyme change,
modify periodontal destruction has not yet been precisely defined. The study aimed to determine the
serum zinc and β D glucuronidase enzyme level in the selected groups and how its increase or decrease
levels are related to type 2 diabetes mellitus (T2DM) with periodontitis when compared to
other groups. Six hundred subjects were selected and are categorized into four groups as Group I
(control healthy subjects, n=150), Group II (T2DM with periodontitis, n=150), Group III (T2DM
without periodontitis, n=150) and Group IV (Non-DM with periodontitis, n=150). The lab investigations
included measuring fasting blood glucose, serum zinc and β D- glucuronidase levels. In the results,
the level of serum zinc was found to be lesser in group III subjects and the activity of serum β
D glucuronidase was found to be elevated nine times in group III (T2DM with periodontitis) and two
times elevated in group II (T2DM without periodontitis) and group IV (Non-DM with periodontitis),
when compared to control. Zinc has been reported to reduce the stabilization of lysosomal membranes.
Periodontitis has been taken as the prime condition in this study and categorized as experimental
groups. Perturbations in mineral metabolism are more pronounced in diabetic populations.
When the level of zinc is decreased, the structural integrity of lysosomal membrane has been lost and
it would have caused for the increased release of β D glucuronidase in T2DM with periodontitis.
Keywords: β D glucuronidase, lysosomal enzymes, membrane stability, type 2 diabetes mellitus, periodontitis, zinc.
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