Current Bioinformatics

Yi-Ping Phoebe Chen
Department of Computer Science and Information Technology
La Trobe University
Melbourne
Australia

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Flux Balance Analysis and Thermodynamics: Trends and Strategies in Disease Biology

Author(s): Tarika Vijayaraghavan, Somnath Tagore.

Abstract:

Computational systems biology emphasizes on modeling biological systems mathematically and computationally for analyzing their role in solving complex processes. One of the applications of systems biology is understanding disease networks, for which various strategies such as, decisionmaking stochastic networks, graph theory based methods, robust control theory, elementary flux modes, extreme pathways, convex analysis, flux variability analysis and phenotype phase planes are used. For judging the stability of a metabolic network, a sound knowledge of bioenergetics as well as free energy concepts regarding metabolic systems are essential. In this manuscript, we have explored the possible application of flux balance analysis in disease networks in correspondence with group contribution method pertaining to the field of thermodynamics for studying the stability of biological systems.

Keywords: Carnitine translocase, flux balance analysis, Gibbs free energy, group contribution method, metabolic network, systems biology.

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Article Details

VOLUME: 10
ISSUE: 3
Year: 2015
Page: [268 - 283]
Pages: 16
DOI: 10.2174/157489361003150723131916
Price: $58