Rapid and Convenient CuCl2 Catalysed Microwave-Assisted Synthesis of Novel Spiro [indoline-3,4'-quinoline] Derivatives

Author(s): Mayuri A. Borad, Manoj N. Bhoi, Darshita M. Patel, Hitesh D. Patel.

Journal Name: Current Microwave Chemistry

Volume 3 , Issue 2 , 2016

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Abstract:

A rapid and efficient, one-pot, three-component, microwave-assisted synthesis of spiro[indoline-3,4'-quinoline] derivatives has been accomplished through three-component Knoevenagel/ Michael addition reaction of isatin, malononitrile and various amine derivative in very good to outstanding yields under CuCl2 catalyst. The main benefits of this protocol are simple work-up, trivial and eco-friendly reaction conditions. Biological characterization, including antibacterial was also evaluated.

Keywords: CuCl2, isatin, microwave-assisted synthesis, multi-component reactions, spiro compound.

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Article Details

VOLUME: 3
ISSUE: 2
Year: 2016
Page: [166 - 172]
Pages: 7
DOI: 10.2174/2213335602666150722232613
Price: $58

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