A rapid and efficient, one-pot, three-component, microwave-assisted synthesis of
spiro[indoline-3,4'-quinoline] derivatives has been accomplished through three-component Knoevenagel/
Michael addition reaction of isatin, malononitrile and various amine derivative in very good to
outstanding yields under CuCl2 catalyst. The main benefits of this protocol are simple work-up, trivial
and eco-friendly reaction conditions. Biological characterization, including antibacterial was also
Keywords: CuCl2, isatin, microwave-assisted synthesis, multi-component reactions, spiro compound.
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