Good at Heart: Preserving Cardiac Metabolism during aging

Author(s): Daniela Sorriento, Antonietta Franco, Maria Rosaria Rusciano, Angela Serena Maione, Maria Soprano, Maddalena Illario, Guido Iaccarino, Michele Ciccarelli.

Journal Name: Current Diabetes Reviews

Volume 12 , Issue 2 , 2016

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Abstract:

The natural process of aging determinates several cardiac modifications with increased susceptibility to heart diseases and ultimately converging on development of chronic heart failure as final stage. These changes mainly include left ventricular hypertrophy, diastolic dysfunction, valvular degeneration, increased cardiac fibrosis, increased prevalence of atrial fibrillation, and decreased maximal exercise capacity, as demonstrated in several humans and animal models of aging. While different theories have been proposed to explain the natural process of aging, it is clear that most of the alterations affect mechanisms involved in cell homeostasis and maintenance. Latest research studies have in particular focused on role of mitochondrial oxidative stress, energy production and mitochondria quality control. This article reviews the central role played by this organelle in aging and the role of new molecular players involved into the progression toward heart failure and potentially susceptible of new “anti-aging” strategies.

Keywords: Aging, heart failure, insulin resistance, metabolism, mitochondria, mitophagy, neurohormonal activation, oxidative stress.

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Article Details

VOLUME: 12
ISSUE: 2
Year: 2016
Page: [90 - 99]
Pages: 10
DOI: 10.2174/1573399811666150722124958
Price: $58

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