Effects of Natural Products on Mcl-1 Expression and Function

Author(s): Florian Muller, Claudia Cerella, Flavia Radogna, Mario Dicato, Marc Diederich.

Journal Name: Current Medicinal Chemistry

Volume 22 , Issue 30 , 2015

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Abstract:

Cancer development is mostly due to a deregulation of cell death as cancer cells become resistant to apoptosis by increasing expression of anti-apoptotic proteins belonging to the Bcl-2 family. Mcl-1 is one anti-apoptotic protein, which is mainly responsible for cancer cell resistance as it is overexpressed by most cancer cell types. Many research projects aim to restore cancer cell death by using natural pharmacological scaffolds targeting anti-apoptotic proteins to inhibit their effect in cancer development. This review introduces natural compound inhibitors of the Bcl-2 protein family with a focus on Mcl-1.

Keywords: apoptosis, cancer, Mcl-1, natural compounds.

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Article Details

VOLUME: 22
ISSUE: 30
Year: 2015
Page: [3447 - 3461]
Pages: 15
DOI: 10.2174/0929867322666150716115435
Price: $58

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