A Novel Class of Emerging Anticancer Compounds: Oxyprenylated Secondary Metabolites from Plants and Fungi

Author(s): Salvatore Genovese, Serena Fiorito, Francesco Epifano, Vito Alessandro Taddeo.

Journal Name: Current Medicinal Chemistry

Volume 22 , Issue 30 , 2015

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Abstract:

O-Prenyl secondary metabolites (3,3-dimethylallyl, geranyl-, farnesyl- and related biosynthetic derivatives) represent a class of rarely occurring natural products. In the last two decades such compounds have been found to exert promising and effective pharmacological activities, mainly in terms of anti-cancer properties. To date about 350 oxyprenylated secondary metabolites, the most part of which having a phenylpropanoid or a polyketide core, have been extracted from plants mainly belonging to the Rutaceae, Apiaceae, and Fabaceae families, and from fungi and bacteria. The aim of this comprehensive review is to make a survey of the in so far reported literature citations about O-prenyl secondary metabolites exhibiting in vitro and in vivo anti-cancer properties from phytochemical and pharmacological point of views.

Keywords: Anthraquinones, cancer, chalcones, cinnamic acids, coumarins, diketopiperazines, oxyprenylated secondary metabolites.

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Article Details

VOLUME: 22
ISSUE: 30
Year: 2015
Page: [3426 - 3433]
Pages: 8
DOI: 10.2174/0929867322666150716114758
Price: $58

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