miR-203 Suppresses the Proliferation and Metastasis of Hepatocellular Carcinoma by Targeting Oncogene ADAM9 and Oncogenic Long Non-coding RNA HULC

Author(s): Daiwei Wan , Shunli Shen , Shunjun Fu , Burnley Preston , Coder Brandon , Songbing He , Chenglong Shen , Jian Wu , Sutong Wang , Wenxuan Xie , Bin Chen , Liya A , Yixing Guo , Dingcheng Zheng , Qiaoming Zhi , Baogang Peng .

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

Volume 16 , Issue 4 , 2016

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Abstract:

MicroRNAs (miRNAs) have been integrated into tumorigenic programs by regulating genes at post-transcriptional level. Long non-coding RNAs (lncRNAs) are novel targets for miRNAs. Here, we reported that miR-203 down-regulation was closely linked to advanced clinical features and poor overall survival (OS) of patients with hepatocellular carcinoma. We also confirmed that miR-203 and oncogene ADAM9 (a disintegrin and metalloproteinase 9)/oncogenic long non-coding RNA HULC (highly up-regulated in liver cancer) were inversely expressed in hepatocellular carcinoma (HCC) tissues or cell lines. More intriguingly, up-regulation of miR-203 diminished the expression of ADAM9 and HULC in HCC cancer cells. Over-expression of miR-203 could markedly inhibit cell proliferation, invasion and induce cell apoptosis. Furthermore, we identified that miR-203 modulated ADAM9 and HULC in a novel post-transcriptional regulatory mechanism. Over-expression of HULC partly rescued the miR-203-mediated antitumor effects. These results suggested that miR-203 played tumor suppressive roles by downregulating ADAM9 and HULC and indicated its potential application in cancer treatment.

Keywords: ADAM9, hepatocellular carcinoma, HULC, long non-coding RNA, microRNA, miR-203.

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Article Details

VOLUME: 16
ISSUE: 4
Year: 2016
Page: [414 - 423]
Pages: 10
DOI: 10.2174/1871520615666150716105955
Price: $58

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