Title:Synthesis, Biological Evaluation, in Silico Docking and Virtual ADME Studies of Novel Isatin Analogs as Promising Antimicrobial Agents
VOLUME: 13 ISSUE: 2
Author(s):Biplab Debnath and Swastika Ganguly
Affiliation:Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi- 835215, Jharkhand, India.
Keywords:Antimicrobial activity, in silico study, lipinski’s rule, Isatin, SAR study.
Abstract:Background: A series of sixteen novel isatin analogs (3a-3p) have been synthesized and
evaluated for their antibacterial and antifungal activities against various pathogenic microorganisms.
Gram-positive bacterial strains: Staphylococcus aureus, Bacillus subtilis; Gram-negative bacterial
strains: Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Klebsiella pneumonia, and fungal
strains Candida albicans, Aspergillus niger use two fold serial dilution method. Methods: Some of
the synthesized compounds showed promising antibacterial and antifungal activities among the series.
Results: Compound 3l shows the best antimicrobial activity which is substantiated by the highest docking
score. Conclusion: Structure activity relationships (SAR) as well as virtual ADMET studies were carried out and a
connection between activities, electronic and physicochemical properties of the target compounds was determined.
