Synthesis, Biological Evaluation, in Silico Docking and Virtual ADME Studies of Novel Isatin Analogs as Promising Antimicrobial Agents

Author(s): Biplab Debnath, Swastika Ganguly.

Journal Name: Anti-Infective Agents

Volume 13 , Issue 2 , 2015

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Background: A series of sixteen novel isatin analogs (3a-3p) have been synthesized and evaluated for their antibacterial and antifungal activities against various pathogenic microorganisms. Gram-positive bacterial strains: Staphylococcus aureus, Bacillus subtilis; Gram-negative bacterial strains: Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Klebsiella pneumonia, and fungal strains Candida albicans, Aspergillus niger use two fold serial dilution method. Methods: Some of the synthesized compounds showed promising antibacterial and antifungal activities among the series. Results: Compound 3l shows the best antimicrobial activity which is substantiated by the highest docking score. Conclusion: Structure activity relationships (SAR) as well as virtual ADMET studies were carried out and a connection between activities, electronic and physicochemical properties of the target compounds was determined.

Keywords: Antimicrobial activity, in silico study, lipinski’s rule, Isatin, SAR study.

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Article Details

Year: 2015
Page: [139 - 153]
Pages: 15
DOI: 10.2174/2211352513666150714180118
Price: $58

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