Genetic Predisposition to Neonatal Tumors
Alberto S. Pappo,
Kim E. Nichols.
The development of tumors within the first month of life is extremely rare and this very
young age at presentation should raise concern for an underlying cancer predisposition syndrome. This
chapter discusses genetic predisposition to neonatal solid tumors, specifically those involving the eyes,
kidneys, liver, adrenal glands and lungs. For each tumor type, we discuss the most common associated
predisposition syndromes and for eye and lung tumors, we also review the approach to diagnosis and
management. The reader is referred to the other chapters of this volume for an overview of management
details for the other tumor types. The management of neonates with cancer predisposing syndromes
is challenging, with many patients demonstrating multisystem involvement. Accordingly, it is
critical to use a team approach, where providers with expertise in neonatology, oncology, genetics, surgery and other
pediatric subspecialties can appropriately tailor management of the patient and coordinate genetic evaluation of the
Keywords: Genetic predisposition, hereditary cancer, neonatal tumor.
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