Background: Bone loss due to congenital or acquired abnormalities of the craniofacial
skeleton is of common occurrence. Surgical repair and reconstruction of the critical size bony defects
are clinically challenging. Of the several approaches, stem cell-based bone-regeneration is gaining
momentum. Stem cells from the orofacial region have been identified as potential source for craniofacial
bone reconstruction as they are derived from cranial neural crest cells. Isolation of orofacial stem
cells is minimally invasive, and they are highly proliferative with the ability to differentiate into multiple
Method: The current review gives a description on mesenchymal stem cells derived from the orofacial region (OMSCs)
and updates the information on their use in bone regeneration.
Results: Studies have reported that OMSCs are highly proliferative with the ability to differentiate into osteogenic lineage.
Various factors influencing osteogenic potential of OMSCs have been discussed.
Conclusion: The findings from the previous literature confirms the potential use of OMSCs in craniofacial bone tissue