Genetic Polymorphisms Might Predict Suicide Attempts in Mental Disorder Patients: A Systematic Review And Meta-Analysis

Author(s): Veronica de Medeiros Alves, Daniele Goncalves Bezerra, Tiago Gomes de Andrade, Valfrido Leao de Melo Neto, Antonio E. Nardi.

Journal Name: CNS & Neurological Disorders - Drug Targets
(Formerly Current Drug Targets - CNS & Neurological Disorders)

Volume 14 , Issue 7 , 2015

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Abstract:

The aim of the present study was to analyze if the genetic polymorphisms might predict suicide attempts in mental disorder patients. The literature review and meta-analysis were conducted using the PubMed/Medline, Web of science and Scopus database using the terms: “5-HTT or SLC6A4 or 5-SERT and suicide, suicidal ideation or suicidal behavior or suicidal attempt”. Thirty articles were analyzed. We found 17 articles that showed association and 13 articles that showed no association between LPR serotonin transporter polymorphism and suicide. A higher study of suicide identified the serotonin transporter polymorphism in patients with schizophrenia, mental disorder, major depression and bipolar disorder. There is an association between the serotonin-transporter-linked polymorphic region and suicidal behavior. The mental disorders with greater relationship with the suicide were the bipolar disorder, major depression and schizophrenia. The L allele had higher risk for suicide.

Keywords: Candidate gene, polymorphism, serotonin, suicidal behavior.

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Article Details

VOLUME: 14
ISSUE: 7
Year: 2015
Page: [820 - 827]
Pages: 8
DOI: 10.2174/1871527314666150713104619
Price: $58

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