The genetic, cellular, and molecular changes associated with Alzheimer disease provide evidence of
immune and inflammatory processes involvement in its pathogenesis. These are supported by epidemiological
studies, which show some benefit of long-term use of NSAID. The hypothesis that AD is in fact an immunologically
mediated and even inflammatory pathological process may be in fact scientifically intriguing. There are several obstacles that suggest
the need for more complex view, in the process of targeting inflammation and immunity in AD. In our previous studies we proposed
a reliable methodology to assess innate immunity in Alzheimer patients and controls. The methodology is based on the phenomenon of
human leukocytes being resistant to viral infection. The unspecific character of the resistance, dependent on interferons and tumor necrosis
factor, and occurrence in cells ex vivo indicate that an in vivo mechanism of innate immunity may be involved. The above mentioned
resistance could be estimated in a test based on peripheral blood leukocytes infection by vesicular stomachs virus.
Keywords: Alzheimer disease, human peripheral blood leukocytes, innate immunity, therapy.
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