Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106
USA

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Notch Signaling in Cancer: Rationale and Strategies for Targeting

Author(s): Aisha Alketbi, Samir Attoub.

Graphical Abstract:


Abstract:

The Notch signaling pathway is a highly conserved system that controls embryonic cell fate decisions and the maintenance of adult stem cells through affecting communication between adjacent cells. The pathway is linked to the development of various cancers owing to increased cell proliferation and tumor blood perfusion in addition to inhibition of apoptosis. Pharmaceutical agents that suppress overactive Notch signaling may be of benefit in the treatment of patients with various cancers. These targeted therapies confer several advantages over conventional anticancer therapies including reduced deleterious effects on normal cells. In this review, we explore the rationale for targeting the Notch signaling pathway in cancer along with different investigational strategies designed to block the pathway.

Keywords: Cancer, monoclonal antibodies, notch inhibitors, notch signaling, γ-secretase inhibitors.

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Article Details

VOLUME: 15
ISSUE: 5
Year: 2015
Page: [364 - 374]
Pages: 11
DOI: 10.2174/156800961505150710113353
Price: $58