Azaheterocyclic compounds are well-known to have diverse types of biological activity.
Among them, azacyclopropanes, commonly referred as aziridines, occupy a prominent place in
synthetic organic and medicinal chemistry due to its occurrence in natural resources, complexity
involved in synthesis due to ring-strain, building blocks in organic synthesis, and its biological
properties. Several novel compounds containing aziridine ring have been designed and synthesized
recently by medicinal chemists for evaluating their biological profile. A number of compounds are
reported as cysteine protease inhibitors, antibacterial, antifungal, anticancer, antileishmanial, and
antimalarial agents. This review article summarizes the biological activity of such compounds. The
preparation of such compounds is also described.