Recent Advances in the Development of Small-Molecular Inhibitors Target HIV Integrase-LEDGF/p75 Interaction

Author(s): Yu Zhao , Zaigang Luo .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 15 , Issue 14 , 2015

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Abstract:

Lens epithelium-derived growth factor (LEDGF/p75) plays an essential role in the HIV-1 replication. It acts by tethering integrase (IN) into the host cellular chromatin. Due to its significance of the IN-LEDGF/p75 interaction affords a novel therapeutic approach for the design of new classes of antiretroviral agents. To date, many small molecules have been found to be the inhibitors of INLEDGF/ p75 interaction. This review summarizes recent advances in the development of potential structure-based IN-LEDGF/p75 interaction inhibitors. The work will be helpful to shed light on the antiretroviral drug development pipeline in the next future.

Keywords: HIV-1; integrase; LEDGF/p75; integrase-LEDGF/p75 interaction inhibitors .

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Article Details

VOLUME: 15
ISSUE: 14
Year: 2015
Page: [1195 - 1208]
Pages: 14
DOI: 10.2174/1389557515666150709114917
Price: $58

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