Potential Roles of Cannabinoids in Cell Therapy for CNS Neurodegenerative Disorders
Pp. 19-40 (22)
Massimo Nabissi, Maria Beatrice Morelli, Consuelo Amantini, Sonia Liberati, Valerio Napolioni, Matteo Santoni, Valerio Farfariello, Claudio Cardinali and Giorgio Santoni
Neural stem cells (NSCs) are self-renewing cells that can differentiate into
multiple neural lineages and repopulate regions of the brain after injury. Mesenchymal
stem cells (MSCs) are multipotent stromal cells that could differentiate into a variety of
cell types, including neuronal cells. Recently, repair of human central nervous system
(CNS) has become a therapeutic approach that is under preclinical investigation for
CNS neurodegenerative disorders (CNSnd). However, CNSnd differ in the types and
groups of cells involved and in the clinical manifestations. Consequently, the cells used
for the potential cellular therapies will depend upon the affected cell population.
Theoretically, NSCs and MSCs have the potential to produce all cell types of the CNS
under specific stimuli, but the molecular targets governing the maturation and the
differentiation of specific neuronal populations are not yet well identified. Cannabinoids
(CBs) by cannabinoid receptors (CB1 and CB2) and by CB related receptors as
Peroxisome proliferator-activated receptor gamma (PPAR-γ) Transient Receptor
Potential Vanilloid type 1 (TRPV1) and type 2 (TRPV2), were found to modulate
neuronal functions including neurogenesis. The aim of this review is to highlight recent
researches regarding CB receptors and CB related receptors, in the regulation of NSCs
differentiation and their potential use in CNSnd stem cell-based therapies.
Cannabinoid Receptors, CNS neurodegenerative disorders, Mesenchimal
stem cells, Neural differentiation, Neural stem cells, Peroxisome proliferator-activated
receptor gamma, Stem cell Therapy, Transient Receptor Potential Channels.
School of Pharmacy, Section of Experimental Medicine, University of Camerino, Camerino, MC, Italy.