Drug resistance primarily appears where there is altered drug metabolism or target
modification. It is a major challenge in cancer therapy which affects treatment process, and limits
chemotherapeutics. Recently, nanotechnological approaches were shown to be capable of lowering
drug side effects and protecting from enzymatic degradation. Therefore, patient’s compliance and
survival rate have dramatically increased. This review elaborates on the structures and functions of
the factors involved in cancer drug resistance together with nanobiotechnological approaches for
overcoming the obstacles in breast cancer research and therapy. The present paper provides information
and suggestions to both basic and clinical researchers to develop new nanobiotechnological methods
to improve breast cancer modalities especially in drug resistance.
Keywords: Breast cancer, drug resistance, nanotechnology, review.
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