Novel α-amino acids bearing 1,2,4-triazinone and steroidal moieties (N,C-disubstituted glycine) (5a and 5b) and the related
systems (6 and 7) have been produced from condensation of 6-(8-aminophenyl)-4-phenyl-3-thioxo-1,2,4-triazin(2H)-5-one (1) with the
selective steroids, 5-α-Androstan-17β-ol-3-one (2a) and Transandrosterone (2b) followed by addition of hydrocyanic acid and acidic hydrolysis.
A nucleophilic substitution of mercapto group by 4-fluoro aniline and sulfanilamide of 5 afforded the corresponding α-amino
acids 6 and 7. These newly synthesis compounds are further evaluated for enzymatic effects against some fungi (Cellobiase activity).
Keywords: Synthesis α-amino acids, cellobiase activities, transandrosterone, triazine, steroid.
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