Antimicrobial peptides (AMPs) have attracted considerable recent interest as potential
therapeutics, motivated by increasing resistance development against conventional antibiotics. This
brief overview summarizes some key aspects related to the interaction of AMPs with bacterial and cell
membranes, as well as with membrane components, which is at the core of the mode-of-action of
these compounds. Throughout, studies on peptide interactions with model lipid membranes and membrane
components are correlated to biological results on antimicrobial and anti-inflammatory effects
of AMPs, and translated into therapeutic considerations.
Keywords: AMP, Anti-inflammatory, Antimicrobial, Bacteria, Membrane, Peptide.
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