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Current Drug Discovery Technologies

Editor-in-Chief

ISSN (Print): 1570-1638
ISSN (Online): 1875-6220

Systems Biology Research into Cardiovascular Disease: Contributions of Lipidomics-based Approaches to Biomarker Discovery

Author(s): Hector De Leon, Stephanie Boue, Justyna Szostak, Manuel C. Peitsch and Julia Hoeng

Volume 12, Issue 3, 2015

Page: [129 - 154] Pages: 26

DOI: 10.2174/1570163812666150702123319

Price: $65

Abstract

Atherosclerosis is a progressive inflammatory thickening of the arterial wall resulting from increased cellularity and the accumulation of lipids, cellular debris, and extracellular matrix. Conventional determinations of plasma lipoproteins have resulted in a wealth of clinical data documenting the correlation between low- and high-density lipoproteins (LDL and HDL) and cardiovascular disease (CVD) risk. Current mass spectrometry methodologies allow the detection and quantification of multiple molecular lipid species with various structural and functional roles. The opportunities provided by lipidomics for lipid-based biomarker discovery are prominent in disease diagnostics, monitoring of drug efficacy, and translational model development. For example, the analysis of human plasma samples assessing the effects of statins has shown correlative effects between the LDL/HDL ratio and sphingomyelin and phosphatidylcholine. Additionally, at the vascular tissue level, lipids from different classes are enriched in human plaques of coronary arteries and in the aortas of apolipoprotein E-deficient mice exposed to cigarette smoke, highlighting a set of lipid biomarkers for translational research. Molecular lipidomics will provide insights in which other lipids may play important roles in vascular disease progression and will serve as novel markers for preventive as well as therapeutic purposes.

Keywords: ApoE-/- mice, lipid biomarkers, lipidomics, mass spectrometry.

Graphical Abstract
[1]
WHO Global atlas on cardiovascular disease prevention and control 2011.
[2]
Ross R. Atherosclerosis--an inflammatory disease. N Engl J Med 1999; 340: 115-26.
[3]
Gepner AD, Piper ME, Johnson HM, Fiore MC, Baker TB, Stein JH. Effects of smoking and smoking cessation on lipids and lipoproteins: Outcomes from a randomized clinical trial. Am Heart J 2011; 161: 145-51.
[4]
Sampson UK, Fazio S, Linton MF. Residual cardiovascular risk despite optimal ldl cholesterol reduction with statins: The evidence, etiology, and therapeutic challenges. Curr Atheroscler Rep 2012; 14: 1-10.
[5]
Lietz M, Berges A, Lebrun S, et al. Cigarette-smoke-induced atherogenic lipid profiles in plasma and vascular tissue of apolipoprotein e-deficient mice are attenuated by smoking cessation. Atherosclerosis 2013; 229: 86-93.
[6]
Dashti M, Kulik W, Hoek F, Veerman EC, Peppelenbosch MP, Rezaee F. A phospholipidomic analysis of all defined human plasma lipoproteins. Sci Rep 2011; 1: 139.
[7]
Stegemann C, Drozdov I, Shalhoub J, et al. Comparative lipidomics profiling of human atherosclerotic plaques. Circulation. Circ Cardiovasc Genet 2011; 4: 232-42.
[8]
Solberg LA, Strong JP. Risk factors and atherosclerotic lesions. A review of autopsy studies. Arteriosclerosis 1983; 3: 187-98.
[9]
Lewis GF, Rader DJ. New insights into the regulation of hdl metabolism and reverse cholesterol transport. Circ Res 2005; 96: 1221-32.
[10]
Goldstein JL, Brown MS. The ldl receptor. Arterioscler Thromb Vasc Biol 2009; 29: 431-8.
[11]
Andrikoula M, McDowell IF. The contribution of apob and apoa1 measurements to cardiovascular risk assessment. Diabetes Obes Metab 2008; 10: 271-8.
[12]
Boren J, Lee I, Zhu W, Arnold K, Taylor S, Innerarity TL. Identification of the low density lipoprotein receptor-binding site in apolipoprotein b100 and the modulation of its binding activity by the carboxyl terminus in familial defective apo-b100. J Clin Invest 1998; 101: 1084-93.
[13]
Gigante B, Leander K, Vikstrom M, et al. Elevated apob serum levels strongly predict early cardiovascular events. Heart 2012; 98: 1242-5.
[14]
Olofsson SO, Boren J. Apolipoprotein b secretory regulation by degradation. Arterioscler Thromb Vasc Biol 2012; 32: 1334-8.
[15]
Boren J, Olin K, Lee I, Chait A, Wight TN, Innerarity TL. Identification of the principal proteoglycan-binding site in ldl. A single-point mutation in apo-b100 severely affects proteoglycan interaction without affecting ldl receptor binding. J Clin Invest 1998; 101: 2658-64.
[16]
Carmena R, Duriez P, Fruchart JC. Atherogenic lipoprotein particles in atherosclerosis. Circulation 2004; 109: III2-7.
[17]
Krauss RM. Dietary and genetic probes of atherogenic dyslipidemia. Arterioscler Thromb Vasc Biol 2005; 25: 2265-72.
[18]
Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502.
[19]
Ridker PM. Ldl cholesterol: Controversies and future therapeutic directions. Lancet 2014; 384: 607-17.
[20]
Raitakari OT, Makinen VP, McQueen MJ, et al. Computationally estimated apolipoproteins b and a1 in predicting cardiovascular risk. Atherosclerosis 2013; 226: 245-51.
[21]
Di Angelantonio E, Gao P, Pennells L, et al. Lipid-related markers and cardiovascular disease prediction. JAMA 2012; 307: 2499-506.
[22]
Mora S, Otvos JD, Rifai N, Rosenson RS, Buring JE, Ridker PM. Lipoprotein particle profiles by nuclear magnetic resonance compared with standard lipids and apolipoproteins in predicting incident cardiovascular disease in women. Circulation 2009; 119: 931-9.
[23]
Khera AV, Everett BM, Caulfield MP, et al. Lipoprotein(a) concentrations, rosuvastatin therapy, and residual vascular risk: An analysis from the jupiter trial (justification for the use of statins in prevention: An intervention trial evaluating rosuvastatin). Circulation 2014; 129: 635-42.
[24]
Sniderman AD, Islam S, Yusuf S, McQueen MJ. Discordance analysis of apolipoprotein b and non-high density lipoprotein cholesterol as markers of cardiovascular risk in the interheart study. Atherosclerosis 2012; 225: 444-9.
[25]
Mora S, Buring JE, Ridker PM. Discordance of low-density lipoprotein (ldl) cholesterol with alternative ldl-related measures and future coronary events. Circulation 2014; 129: 553-61.
[26]
Price JF, Mowbray PI, Lee AJ, Rumley A, Lowe GD, Fowkes FG. Relationship between smoking and cardiovascular risk factors in the development of peripheral arterial disease and coronary artery disease: Edinburgh artery study. Eur Heart J 1999; 20: 344-53.
[27]
Surgeon_General Cardiovascular diseases In: Multiple, ed How tobacco smoke causes disease: The biology and behavioral basis for smoking-attributable disease: A report of the surgeon general Atlanta (GA): The Surgeon General 2010; 351-434.
[28]
Bakhru A, Erlinger TP. Smoking cessation and cardiovascular disease risk factors: Results from the third national health and nutrition examination survey. PLoS Med 2005; 2: e160.
[29]
Freedman DS, Srinivasan SR, Shear CL, et al. Cigarette smoking initiation and longitudinal changes in serum lipids and lipoproteins in early adulthood: The bogalusa heart study. Am J Epidemiol 1986; 124: 207-19.
[30]
Al-Daghri NM. Acute post cessation smoking. A strong predictive factor for metabolic syndrome among adult saudis. Saudi Med J 2009; 30: 267-71.
[31]
Gao S, Wang YH, Li M. Cigarette smoking increases levels of retinol-binding protein-4 in healthy men with normal glucose tolerance. Chin Med J (Engl) 2012; 125: 1686-9.
[32]
Hayase T, Ayaori M, Sato H, et al. Impact of low-and high-density lipoprotein cholesterol levels on carotid intima-media thickness differs by smoking status in middle-aged men. J Atheroscler Thromb 2012; 19: 664-72.
[33]
Lavie L, Lavie P. Smoking interacts with sleep apnea to increase cardiovascular risk. Sleep Med 2008; 9: 247-53.
[34]
Al-Tamer YY, Mahmood AA. Lipid components and fatty acid composition of iraqi subjects who smoke and consume dairy products. Nutr Metab Cardiovasc Dis 2004; 14: 94-6.
[35]
Hofer SE, Rosenbauer J, Grulich-Henn J, et al. Smoking and metabolic control in adolescents with type 1 diabetes. J Pediatr 2009; 154: 20-3.
[36]
Hussain T, Al-Daghri NM, Al-Attas OS, Draz HM, Abd Al-Rahman SH, Yakout SM. Plasma neuropeptide y levels relate cigarette smoking and smoking cessation to body weight regulation. Regul Pept 2012; 176: 22-7.
[37]
Kelishadi R, Sadry G, Zadegan NS, et al. Smoking, adolescents and health: Isfahan healthy heart programme-heart health promotion from childhood Asia-Pacific journal of public health / Asia-Pacific Academic Consortium for Public Health 2004; 16: 15-22.
[38]
Rao ChS, Subash YE. The effect of chronic tobacco smoking and chewing on the lipid profile. J Clin Diagn Res 2013; 7: 31-4.
[39]
Sharma SB, Dwivedi S, Prabhu KM, Singh G, Kumar N, Lal MK. Coronary risk variables in young asymptomatic smokers. Indian J Med Res 2005; 122: 205-10.
[40]
Bergman BC, Perreault L, Hunerdosse DM, Koehler MC, Samek AM, Eckel RH. Intramuscular lipid metabolism in the insulin resistance of smoking. Diabetes 2009; 58: 2220-7.
[41]
Mammas IN, Bertsias GK, Linardakis M, Tzanakis NE, Labadarios DN, Kafatos AG. Cigarette smoking, alcohol consumption, and serum lipid profile among medical students in greece. Eur J Public Health 2003; 13: 278-82.
[42]
Sanada S, Nishida M, Ishii K, Moriyama T, Komuro I, Yamauchi-Takihara K. Smoking promotes subclinical atherosclerosis in apparently healthy men: 2-year ultrasonographic follow-up Circulation journal: official journal of the Japanese Circulation Society 2012; 76: 2884-91.
[43]
Al Mutairi SS, Mojiminiyi OA, Shihab-Eldeen AA, Al Sharafi A, Abdella N. Effect of smoking habit on circulating adipokines in diabetic and non-diabetic subjects. Ann Nutr Metab 2008; 52: 329-34.
[44]
Meenakshisundaram R, Rajendiran C, Thirumalaikolundusubramanian P. Lipid and lipoprotein profiles among middle aged male smokers: A study from southern india. Tob Induc Dis 2010; 8: 11.
[45]
Padmavathi P, Reddy VD, Maturu P, Varadacharyulu N. Smoking-induced alterations in platelet membrane fluidity and na(+)/k(+)-atpase activity in chronic cigarette smokers. J Atheroscler Thromb 2010; 17: 619-27.
[46]
Imamura H, Miyamoto N, Uchida K, Teshima K, Masuda Y, Kobata D. Cigarette smoking, blood pressure and serum lipids and lipoproteins in middle-aged women. J Physiol Anthropol Appl Human Sci 2001; 20: 1-6.
[47]
Wakabayashi I. Associations between alcohol drinking and multiple risk factors for atherosclerosis in smokers and nonsmokers. Angiology 2010; 61: 495-503.
[48]
Yasue H, Hirai N, Mizuno Y, et al. Low-grade inflammation, thrombogenicity, and atherogenic lipid profile in cigarette smokers Circulation journal : official journal of the Japanese Circulation Society 2006; 70: 8-13.
[49]
S AL, Lakshmanan A, P GK. A S. Effect of intensity of cigarette smoking on haematological and lipid parameters. J Clin Diagn Res 2014; 8: BC11-3.
[50]
Chapman MJ. Therapeutic elevation of hdl-cholesterol to prevent atherosclerosis and coronary heart disease. Pharmacol Ther 2006; 111: 893-908.
[51]
Singh IM, Shishehbor MH, Ansell BJ. High-density lipoprotein as a therapeutic target: A systematic review. JAMA 2007; 298: 786-98.
[52]
Chapman MJ, Assmann G, Fruchart JC, Shepherd J, Sirtori C. European Consensus Panel on H-C. Raising high-density lipoprotein cholesterol with reduction of cardiovascular risk: The role of nicotinic acid--a position paper developed by the european consensus panel on hdl-c. Curr Med Res Opin 2004; 20: 1253-68.
[53]
Cooney MT, Dudina A, De Bacquer D, et al. Hdl cholesterol protects against cardiovascular disease in both genders, at all ages and at all levels of risk. Atherosclerosis 2009; 206: 611-6.
[54]
Nofer JR, Kehrel B, Fobker M, Levkau B, Assmann G, von Eckardstein A. Hdl and arteriosclerosis: Beyond reverse cholesterol transport. Atherosclerosis 2002; 161: 1-16.
[55]
Norata GD, Pirillo A, Catapano AL. Modified hdl: Biological and physiopathological consequences. Nutr Metab Cardiovasc Dis 2006; 16: 371-86.
[56]
Freeman DJ, Griffin BA, Murray E, et al. Smoking and plasma lipoproteins in man: Effects on low density lipoprotein cholesterol levels and high density lipoprotein subfraction distribution. Eur J Clin Invest 1993; 23: 630-40.
[57]
Haffner SM, Applebaum-Bowden D, Wahl PW, et al. Epidemiological correlates of high density lipoprotein subfractions, apolipoproteins a-i, a-ii, and d, and lecithin cholesterol acyltransferase. Effects of smoking, alcohol, and adiposity. Arteriosclerosis 1985; 5: 169-77.
[58]
Kong C, Nimmo L, Elatrozy T, et al. Smoking is associated with increased hepatic lipase activity, insulin resistance, dyslipidaemia and early atherosclerosis in type 2 diabetes. Atherosclerosis 2001; 156: 373-8.
[59]
Meilahn EN, Kuller LH, Stein EA, Caggiula AW, Matthews KA. Characteristics associated with apoprotein and lipoprotein lipid levels in middle-aged women. Arteriosclerosis 1988; 8: 515-20.
[60]
Moffatt RJ, Biggerstaff KD, Stamford BA. Effects of the transdermal nicotine patch on normalization of hdl-c and its subfractions. Prev Med 2000; 31: 148-52.
[61]
Richard F, Marecaux N, Dallongeville J, et al. Effect of smoking cessation on lipoprotein a-i and lipoprotein a-i:A-ii levels. Metabolism 1997; 46: 711-5.
[62]
Unverdorben M, von Holt K, Winkelmann BR. Smoking and atherosclerotic cardiovascular disease: Part ii: Role of cigarette smoking in cardiovascular disease development. Biomarkers Med 2009; 3: 617-53.
[63]
Hughes K, Choo M, Kuperan P, Ong CN, Aw TC. Cardiovascular risk factors in relation to cigarette smoking: A population-based survey among asians in singapore. Atherosclerosis 1998; 137: 253-8.
[64]
Craig WY, Palomaki GE, Haddow JE. Cigarette smoking and serum lipid and lipoprotein concentrations: An analysis of published data. BMJ 1989; 298: 784-8.
[65]
Eliasson B, Hjalmarson A, Kruse E, Landfeldt B, Westin A. Effect of smoking reduction and cessation on cardiovascular risk factors. Nicotine Tob Res 2001; 3: 249-55.
[66]
Johnson HM, Gossett LK, Piper ME, et al. Effects of smoking and smoking cessation on endothelial function: 1-year outcomes from a randomized clinical trial. J Am Coll Cardiol 2010; 55: 1988-95.
[67]
Komiyama M, Wada H, Ura S, et al. Analysis of factors that determine weight gain during smoking cessation therapy. PLoS One 2013; 8: e72010.
[68]
Minami J, Todoroki M, Yoshii M, et al. Effects of smoking cessation or alcohol restriction on metabolic and fibrinolytic variables in japanese men. Clin Sci (Lond) 2002; 103: 117-22.
[69]
Noh JM, Lee SH, Kim HW, Yang HS. Changes in the serum level of high density lipoprotein-cholesterol after smoking cessation among adult men. Korean J Fam Med 2012; 33: 305-10.
[70]
Suwazono Y, Dochi M, Oishi M, Tanaka K, Morimoto H, Sakata K. Longitudinal effect of smoking cessation on physical and laboratory findings. Am J Prev Med 2010; 38: 192-200.
[71]
Tamura U, Tanaka T, Okamura T, et al. Changes in weight, cardiovascular risk factors and estimated risk of coronary heart disease following smoking cessation in japanese male workers: Hipop-ohp study. J Atheroscler Thromb 2010; 17: 12-20.
[72]
Calo WA, Ortiz AP, Suarez E, Guzman M, Perez CM, Perez CM. Association of cigarette smoking and metabolic syndrome in a puerto rican adult population. J Immigr Minor Health 2013; 15: 810-6.
[73]
Ferrara CM, Kumar M, Nicklas B, McCrone S, Goldberg AP. Weight gain and adipose tissue metabolism after smoking cessation in women. Int J Obes Relat Metab Disord 2001; 25: 1322-6.
[74]
Lee SS, Seo JS, Kim SR, et al. The changes of blood glucose control and lipid profiles after short-term smoking cessation in healthy males. Psychiatry Investig 2011; 8: 149-54.
[75]
Yan-Ling Z, Dong-Qing Z, Chang-Quan H, Bi-Rong D. Cigarette smoking and its association with serum lipid/lipoprotein among chinese nonagenarians/centenarians. Lipids Health Dis 2012; 11: 94.
[76]
Yoon C, Goh E, Park SM, Cho B. Effects of smoking cessation and weight gain on cardiovascular disease risk factors in asian male population. Atherosclerosis 2010; 208: 275-9.
[77]
Feher MD, Caslake M, Foxton J, Cox A, Packard CJ. Atherogenic lipoprotein phenotype in type 2 diabetes: Reversal with micronised fenofibrate. Diabetes Metab Res Rev 1999; 15: 395-9.
[78]
Eliasson B, Attvall S, Taskinen MR, Smith U. Smoking cessation improves insulin sensitivity in healthy middle-aged men. Eur J Clin Invest 1997; 27: 450-6.
[79]
Watanabe H, Soderlund S, Soro-Paavonen A, et al. Decreased high-density lipoprotein (hdl) particle size, prebeta-, and large hdl subspecies concentration in finnish low-hdl families: Relationship with intima-media thickness. Arterioscler Thromb Vasc Biol 2006; 26: 897-902.
[80]
Powell JT, Edwards RJ, Worrell PC, Franks PJ, Greenhalgh RM, Poulter NR. Risk factors associated with the development of peripheral arterial disease in smokers: A case-control study. Atherosclerosis 1997; 129: 41-8.
[81]
Drexel H, Steurer J, Muntwyler J, et al. Predictors of the presence and extent of peripheral arterial occlusive disease. Circulation 1996; 94: II199-205.
[82]
Bertoia ML, Pai JK, Lee JH, et al. Oxidation-specific biomarkers and risk of peripheral artery disease. J Am Coll Cardiol 2013; 61: 2169-79.
[83]
Koskinen J, Magnussen CG, Wurtz P, et al. Apolipoprotein b, oxidized low-density lipoprotein, and ldl particle size in predicting the incidence of metabolic syndrome: The cardiovascular risk in young finns study. Eur J Prev Cardiol 2012; 19: 1296-303.
[84]
Tognon G, Berg C, Mehlig K, et al. Comparison of apolipoprotein (apob/apoa-i) and lipoprotein (total cholesterol/hdl) ratio determinants. Focus on obesity, diet and alcohol intake. PLoS One 2012; 7: e40878.
[85]
Lee KW, Hill JS, Walley KR, Frohlich JJ. Relative value of multiple plasma biomarkers as risk factors for coronary artery disease and death in an angiography cohort CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2006; 174: 461-6.
[86]
Parthasarathy S, Steinbrecher UP, Barnett J, Witztum JL, Steinberg D. Essential role of phospholipase a2 activity in endothelial cell-induced modification of low density lipoprotein. Proc Natl Acad Sci USA 1985; 82: 3000-4.
[87]
Yokode M, Kita T, Arai H, Kawai C, Narumiya S, Fujiwara M. Cholesteryl ester accumulation in macrophages incubated with low density lipoprotein pretreated with cigarette smoke extract. Proc Natl Acad Sci USA 1988; 85: 2344-8.
[88]
Lenz ML, Hughes H, Mitchell JR, et al. Lipid hydroperoxy and hydroxy derivatives in copper-catalyzed oxidation of low density lipoprotein. J Lipid Res 1990; 31: 1043-50.
[89]
Frei B, Forte TM, Ames BN, Cross CE. Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid. The Biochem J 1991; 277(Pt 1): 133-8.
[90]
Sekher Pannala A, Bruckdorfer KR, Rice-Evans CA. Smoking has no effect on the amino acid composition of apolipoprotein b100 of ldl while directly influencing the antioxidant status. Biochem Biophys Res Commun 2002; 292: 175-83.
[91]
Kralova Lesna I, Poledne R, Pagacova L, Stavek P, Pitha J. Hdl and apolipoprotein a1 concentrations as markers of cholesterol efflux in middle-aged women: Interaction with smoking. Neuroendocrinol Lett 2012; 33(Suppl. 2): 38-42.
[92]
Qureshi AI, Giles WH, Croft JB, Guterman LR, Hopkins LN. Apolipoproteins a-1 and b and the likelihood of non-fatal stroke and myocardial infarction -- data from the third national health and nutrition examination survey. Med Sci Monit 2002; 8: CR311-6.
[93]
Parish S, Peto R, Palmer A, et al. The joint effects of apolipoprotein b, apolipoprotein a1, ldl cholesterol, and hdl cholesterol on risk: 3510 cases of acute myocardial infarction and 9805 controls. Eur Heart J 2009; 30: 2137-46.
[94]
Gazi I, Lourida ES, Filippatos T, Tsimihodimos V, Elisaf M, Tselepis AD. Lipoprotein-associated phospholipase a2 activity is a marker of small, dense ldl particles in human plasma. Clin Chem 2005; 51: 2264-73.
[95]
Hatoum IJ, Cook NR, Nelson JJ, Rexrode KM, Rimm EB. Lipoprotein-associated phospholipase a2 activity improves risk discrimination of incident coronary heart disease among women. Am Heart J 2011; 161: 516-22.
[96]
Boekholdt SM, Keller TT, Wareham NJ, et al. Serum levels of type ii secretory phospholipase a2 and the risk of future coronary artery disease in apparently healthy men and women: The epic-norfolk prospective population study. Arterioscler Thromb Vasc Biol 2005; 25: 839-46.
[97]
Lavi S, Prasad A, Yang EH, et al. Smoking is associated with epicardial coronary endothelial dysfunction and elevated white blood cell count in patients with chest pain and early coronary artery disease. Circulation 2007; 115: 2621-7.
[98]
Boue S, Tarasov K, Janis M, et al. Modulation of atherogenic lipidome by cigarette smoke in apolipoprotein e-deficient mice. Atherosclerosis 2012; 225: 328-34.
[99]
Dahlen SE, Raud J, Serhan CN, Bjork J, Samuelsson B. Biological activities of lipoxin a include lung strip contraction and dilation of arterioles in vivo. Acta Physiol Scand 1987; 130: 643-7.
[100]
Samuelsson B, Dahlen SE, Lindgren JA, Rouzer CA, Serhan CN. Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects. Science 1987; 237: 1171-6.
[101]
Boyce JA. Eicosanoids in asthma, allergic inflammation, and host defense. Curr Mol Med 2008; 8: 335-49.
[102]
Roman RJ. P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev 2002; 82: 131-85.
[103]
Hao CM, Breyer MD. Physiologic and pathophysiologic roles of lipid mediators in the kidney. Kidney Inl 2007; 71: 1105-15.
[104]
Shearer GC, Newman JW. Impact of circulating esterified eicosanoids and other oxylipins on endothelial function. Curr Atheroscler Rep 2009; 11: 403-10.
[105]
Messner B, Bernhard D. Smoking and cardiovascular disease: Mechanisms of endothelial dysfunction and early atherogenesis. Arterioscler Thromb Vasc Biol 2014; 34: 509-15.
[106]
Raveendran M, Wang J, Senthil D, et al. Endogenous nitric oxide activation protects against cigarette smoking induced apoptosis in endothelial cells. FEBS Lett 2005; 579: 733-40.
[107]
Nordskog BK, Fields WR, Hellmann GM. Kinetic analysis of cytokine response to cigarette smoke condensate by human endothelial and monocytic cells. Toxicology 2005; 212: 87-97.
[108]
Wang H, Ye Y, Zhu M, Cho C. Increased interleukin-8 expression by cigarette smoke extract in endothelial cells. Environ Toxicol Pharmacol 2000; 9: 19-23.
[109]
Nordskog BK, Blixt AD, Morgan WT, Fields WR, Hellmann GM. Matrix-degrading and pro-inflammatory changes in human vascular endothelial cells exposed to cigarette smoke condensate. Cardiovasc Toxicol 2003; 3: 101-17.
[110]
Henderson B, Csordas A, Backovic A, Kind M, Bernhard D, Wick G. Cigarette smoke is an endothelial stressor and leads to cell cycle arrest. Atherosclerosis 2008; 201: 298-305.
[111]
Nishio E, Watanabe Y. Cigarette smoke extract is a modulator of mitogenic action in vascular smooth muscle cells. Life Sci 1998; 62: 1339-47.
[112]
Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation 2002; 105: 1135-43.
[113]
von Holt K, Lebrun S, Stinn W, Conroy L, Wallerath T, Schleef R. Progression of atherosclerosis in the apo e-/- model: 12-month exposure to cigarette mainstream smoke combined with high-cholesterol/fat diet. Atherosclerosis 2009; 205: 135-43.
[114]
Schroeter MR, Sawalich M, Humboldt T, et al. Cigarette smoke exposure promotes arterial thrombosis and vessel remodeling after vascular injury in apolipoprotein e-deficient mice. J Vasc Res 2008; 45: 480-92.
[115]
Boue S, De Leon H, Schlage WK, et al. Cigarette smoke induces molecular responses in respiratory tissues of apoe(-/-) mice that are progressively deactivated upon cessation. Toxicology 2013; 314: 112-24.
[116]
Wang L, Chen L, Tan Y, et al. Betaine supplement alleviates hepatic triglyceride accumulation of apolipoprotein e deficient mice via reducing methylation of peroxisomal proliferator-activated receptor alpha promoter. Lipids Health Dis 2013; 12: 34.
[117]
Conklin DJ, Barski OA, Lesgards JF, et al. Acrolein consumption induces systemic dyslipidemia and lipoprotein modification. Toxicol Appl Pharmacol 2010; 243: 1-12.
[118]
Plump AS, Breslow JL. Apolipoprotein e and the apolipoprotein e-deficient mouse. Annu Rev Nutr 1995; 15: 495-518.
[119]
Ha YC, Barter PJ. Differences in plasma cholesteryl ester transfer activity in sixteen vertebrate species. Comp Biochem Physiol B 1982; 71: 265-9.
[120]
Birner-Gruenberger R, Schittmayer M, Holzer M, Marsche G. Understanding high-density lipoprotein function in disease: Recent advances in proteomics unravel the complexity of its composition and biology. Prog Lipid Res 2014; 56C: 36-46.
[121]
Alwaili K, Bailey D, Awan Z, et al. The hdl proteome in acute coronary syndromes shifts to an inflammatory profile. Biochim Biophys Acta 2012; 1821: 405-15.
[122]
Vaisar T, Pennathur S, Green PS, et al. Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of hdl. J Clin Invest 2007; 117: 746-56.
[123]
Maceyka M, Spiegel S. Sphingolipid metabolites in inflammatory disease. Nature 2014; 510: 58-67.
[124]
Puri R, Duong M, Uno K, Kataoka Y, Nicholls SJ. The emerging role of plasma lipidomics in cardiovascular drug discovery. Expert Opin Drug Discov 2012; 7: 63-72.
[125]
Platt FM. Sphingolipid lysosomal storage disorders. Nature 2014; 510: 68-75.
[126]
Allende ML, Proia RL. Simplifying complexity: Genetically resculpting glycosphingolipid synthesis pathways in mice to reveal function. Glycoconj J 2014; 31(9): 613-22.
[127]
Ekroos K, Janis M, Tarasov K, Hurme R, Laaksonen R. Lipidomics: A tool for studies of atherosclerosis. Curr Atheroscler Rep 2010; 12: 273-81.
[128]
Tucker SC, Honn KV. Emerging targets in lipid-based therapy. Biochem Pharmacol 2013; 85: 673-88.
[129]
Fahy E, Subramaniam S, Murphy RC, et al. Update of the lipid maps comprehensive classification system for lipids. J Lipid Res 2009; 50(Suppl.): S9-S14.
[130]
Wiesner P, Leidl K, Boettcher A, Schmitz G, Liebisch G. Lipid profiling of fplc-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry. J Lipid Res 2009; 50: 574-85.
[131]
Jukema JW, Liem AH, Dunselman PH, van der Sloot JA, Lok DJ, Zwinderman AH. Ldl-c/hdl-c ratio in subjects with cardiovascular disease and a low hdl-c: Results of the radar (rosuvastatin and atorvastatin in different dosages and reverse cholesterol transport) study. Curr Med Res Opin 2005; 21: 1865-74.
[132]
Bergheanu SC, Reijmers T, Zwinderman AH, et al. Lipidomic approach to evaluate rosuvastatin and atorvastatin at various dosages: Investigating differential effects among statins. Curr Med Res Opin 2008; 24: 2477-87.
[133]
Winkelmann BR, Marz W, Boehm BO, et al. Rationale and design of the luric study--a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease. Pharmacogenomics 2001; 2: S1-S73.
[134]
Tarasov K, Ekroos K, Suoniemi M, et al. Molecular lipids identify cardiovascular risk and are efficiently lowered by simvastatin and pcsk9 deficiency. J Clin Endocrinol Metab 2014; 99: E45-52.
[135]
De Leon H, Boue S, Peitsch MC, Hoeng J. Modulation of the hepatic lipidome and transcriptome of apoe-/- mice in response to smoking cessation. J Liver 2013; •••: 2.
[136]
Didangelos A, Stegemann C, Mayr M. The -omics era: Proteomics and lipidomics in vascular research. Atherosclerosis 2012; 221: 12-7.
[137]
Balgoma D, Checa A, Sar DG, Snowden S, Wheelock CE. Quantitative metabolic profiling of lipid mediators. Mol Nutr Food Res 2013; 57: 1359-77.
[138]
Scherer M, Schmitz G, Liebisch G. High-throughput analysis of sphingosine 1-phosphate, sphinganine 1-phosphate, and lysophosphatidic acid in plasma samples by liquid chromatography-tandem mass spectrometry. Clin Chem 2009; 55: 1218-22.
[139]
Heiskanen LA, Suoniemi M, Ta HX, Tarasov K, Ekroos K. Long-term performance and stability of molecular shotgun lipidomic analysis of human plasma samples. Anal Chem 2013; 85: 8757-63.
[140]
Yang W, Chen Y, Xi C, et al. Liquid chromatography-tandem mass spectrometry-based plasma metabonomics delineate the effect of metabolites’ stability on reliability of potential biomarkers. Anal Chem 2013; 85: 2606-10.
[141]
Laurila PP, Surakka I, Sarin AP, et al. Genomic, transcriptomic, and lipidomic profiling highlights the role of inflammation in individuals with low high-density lipoprotein cholesterol. Arterioscler Thromb Vasc Biol 2013; 33: 847-57.
[142]
Bruckert E, Labreuche J, Amarenco P. Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis. Atherosclerosis 2010; 210: 353-61.
[143]
Barcin C, Tapan S, Kursaklioglu H, et al. Effects of non-heavy smoking on high-density lipoprotein cholesterol in healthy turkish young men. Acta cardiologica 2006; 61: 411-5.
[144]
Bergman BC, Perreault L, Hunerdosse D, et al. Novel and reversible mechanisms of smoking-induced insulin resistance in humans. Diabetes 2012; 61: 3156-66.
[145]
Chen CC, Li TC, Chang PC, et al. Association among cigarette smoking, metabolic syndrome, and its individual components: The metabolic syndrome study in taiwan. Metabolism 2008; 57: 544-8.
[146]
Fisher SD, Zareba W, Moss AJ, et al. Effect of smoking on lipid and thrombogenic factors two months after acute myocardial infarction. Am J Cardiol 2000; 86: 813-8.
[147]
Holay MP, Paunikar NP, Joshi PP, Sahasrabhojney VS, Tankhiwale SR. Effect of passive smoking on endothelial function in: Healthy adults. J Assoc Physicians India 2004; 52: 114-7.
[148]
Imamura H, Uchida K, Kobata D. Relationship of cigarette smoking with blood pressure, serum lipids and lipoproteins in young japanese women. Clin Exp Pharmacol Physiol 2000; 27: 364-9.
[149]
Imamura H, Teshima K, Miyamoto N, Shirota T. Cigarette smoking, high-density lipoprotein cholesterol subfractions, and lecithin: Cholesterol acyltransferase in young women. Metabolism: clinical and experimental 2002; 51: 1313-6.
[150]
Jiang CQ, Xu L, Lam TH, Lin JM, Cheng KK, Thomas GN. Smoking cessation and carotid atherosclerosis: The guangzhou biobank cohort study--cvd. J Epidemiol Community Health 2010; 64: 1004-9.
[151]
Kassi E, Dalamaga M, Faviou E, et al. Circulating oxidized ldl levels, current smoking and obesity in postmenopausal women. Atherosclerosis 2009; 205: 279-83.
[152]
Kondo T, Hayashi M, Takeshita K, et al. Smoking cessation rapidly increases circulating progenitor cells in peripheral blood in chronic smokers. Arterioscler Thromb Vasc Biol 2004; 24: 1442-7.
[153]
Kuzuya M, Ando F, Iguchi A, Shimokata H. Effect of smoking habit on age-related changes in serum lipids: A cross-sectional and longitudinal analysis in a large japanese cohort. Atherosclerosis 2006; 185: 183-90.
[154]
Lopes PA, Santos MC, Vicente L, Viegas-Crespo AM. Effect of cigarette smoking on serum alpha-tocopherol and the lipid profile in a portuguese population. Clin Chim Acta 2004; 348: 49-55.
[155]
Mackowiak K, Nowicki M, Wysocka E, Brozek A, Torlinski L. The impact of tobacco smoking on the selected risk factors for cardiovascular disease in students of poznan university of medical sciences. Przegl Lek 2012; 69: 819-23.
[156]
Moffatt RJ, Chelland SA, Pecott DL, Stamford BA. Acute exposure to environmental tobacco smoke reduces hdl-c and hdl2-c. Prev Med 2004; 38: 637-41.
[157]
Shearman AM, Demissie S, Cupples LA, et al. Tobacco smoking, estrogen receptor alpha gene variation and small low density lipoprotein level. Hum Mol Genet 2005; 14: 2405-13.
[158]
Teshima K, Imamura H, Uchida K, Miyamoto N, Masuda Y, Kobata D. Cigarette smoking, blood pressure and serum lipids in japanese men aged 20-39 years. J Physiol Anthropol Appl Human Sci 2001; 20: 43-5.
[159]
van den Berkmortel FW, Demacker PN, Wollersheim H, Thien T, Stalenhoef AF. Smoking or its cessation does not alter the susceptibility to in vitro ldl oxidation. Eur J Clin Invest 2000; 30: 972-9.
[160]
Erguder IB, Erguder T, Ozkan C, et al. Short-term effects of smoking cessation on blood antioxidant parameters and paraoxonase activity in healthy asymptomatic long-term cigarette smokers. Inhal Toxicol 2006; 18: 575-9.
[161]
Iino K, Iwase M, Tsutsu N, Iida M. Smoking cessation and glycaemic control in type 2 diabetic patients. Diabetes Obes Metab 2004; 6: 181-6.
[162]
Korhonen T, Goodwin A, Miesmaa P, Dupuis EA, Kinnunen T. Smoking cessation program with exercise improves cardiovascular disease biomarkers in sedentary women. J Womens Health (Larchmt) 2011; 20: 1051-64.
[163]
Tonstad S, Urdal P. Does short-term smoking cessation reduce plasma total homocysteine concentrations? Scand J Clin Lab Invest 2002; 62: 279-84.
[164]
Centre NCG. Nice clinical guideline cg181: Lipid modification: Cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease 2014.
[165]
Athyros VG, Papageorgiou AA, Mercouris BR, et al. Treatment with atorvastatin to the national cholesterol educational program goal versus ‘usual’ care in secondary coronary heart disease prevention. The greek atorvastatin and coronary-heart-disease evaluation (greace) study. Curr Med Res Opin 2002; 18: 220-8.
[166]
Koren MJ, Hunninghake DB, Investigators A. Clinical outcomes in managed-care patients with coronary heart disease treated aggressively in lipid-lowering disease management clinics: The alliance study. J Am Coll Cardiol 2004; 44: 1772-9.
[167]
Amarenco P, Bogousslavsky J, Callahan A III, et al. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med 2006; 355: 549-59.
[168]
Riegger G, Abletshauser C, Ludwig M, et al. The effect of fluvastatin on cardiac events in patients with symptomatic coronary artery disease during one year of treatment. Atherosclerosis 1999; 144: 263-70.
[169]
Lesaffre E, Kocmanova D, Lemos PA, Disco CM, Serruys PW. A retrospective analysis of the effect of noncompliance on time to first major adverse cardiac event in lips. Clin Ther 2003; 25: 2431-47.
[170]
Results of the low-dose (20 mg) pravastatin gissi prevenzione trial in 4271 patients with recent myocardial infarction: Do stopped trials contribute to overall knowledge? Gissi prevenzione investigators (gruppo italiano per lo studio della sopravvivenza nell'infarto miocardico). Italian heart journal : official journal of the Italian Federation of Cardiology 2000; 1: 810-20.
[171]
Yokoi H, Nobuyoshi M, Mitsudo K, Kawaguchi A, Yamamoto A, Investigators AS. Three-year follow-up results of angiographic intervention trial using an hmg-coa reductase inhibitor to evaluate retardation of obstructive multiple atheroma (atheroma) study. Circulation J 2005; 69: 875-83.
[172]
Byington RP, Furberg CD, Crouse JR III, Espeland MA, Bond MG. Pravastatin, lipids, and atherosclerosis in the carotid arteries (plac-ii). Am J Cardiol 1995; 76: 54C-9C.
[173]
Pitt B, Mancini GB, Ellis SG, Rosman HS, Park JS, McGovern ME. Pravastatin limitation of atherosclerosis in the coronary arteries (plac i): Reduction in atherosclerosis progression and clinical events. Plac i investigation. Am J Cardiol 1995; 26: 1133-9.
[174]
Sacks FM, Pfeffer MA, Moye LA, et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and recurrent events trial investigators. N Engl J Med 1996; 335: 1001-9.
[175]
Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. The long-term intervention with pravastatin in ischaemic disease (lipid) study group. N Engl J Med 1998; 339: 1349-57.
[176]
Shepherd J, Blauw GJ, Murphy MB, et al. Pravastatin in elderly individuals at risk of vascular disease (prosper): A randomised controlled trial. Lancet 2002; 360: 1623-30.
[177]
Teo KK, Burton JR, Buller CE, et al. Long-term effects of cholesterol lowering and angiotensin-converting enzyme inhibition on coronary atherosclerosis: The simvastatin/enalapril coronary atherosclerosis trial (scat). Circulation 2000; 102: 1748-54.
[178]
Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The scandinavian simvastatin survival study (4s). Lancet 1994; 344: 1383-9.
[179]
Heart Protection Study Collaborative G. Mrc/bhf heart protection study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: A randomised placebo-controlled trial. Lancet 2002; 360: 7-22.
[180]
Sever PS, Dahlof B, Poulter NR, et al. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the anglo-scandinavian cardiac outcomes trial--lipid lowering arm (ascot-lla): A multicentre randomised controlled trial. Lancet 2003; 361: 1149-58.
[181]
Anderssen SA, Hjelstuen AK, Hjermann I, Bjerkan K, Holme I. Fluvastatin and lifestyle modification for reduction of carotid intima-media thickness and left ventricular mass progression in drug-treated hypertensives. Atherosclerosis 2005; 178: 387-97.
[182]
Nakamura H, Arakawa K, Itakura H, et al. Primary prevention of cardiovascular disease with pravastatin in japan (mega study): A prospective randomised controlled trial. Lancet 2006; 368: 1155-63.
[183]
Shepherd J, Cobbe SM, Ford I, et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of scotland coronary prevention study group. N Engl J Med 1995; 333: 1301-7.
[184]
Mercuri M, Bond MG, Sirtori CR, et al. Pravastatin reduces carotid intima-media thickness progression in an asymptomatic hypercholesterolemic mediterranean population: The carotid atherosclerosis italian ultrasound study. The Am J Med 1996; 101: 627-34.
[185]
Officers A. Coordinators for the ACRGTA, Lipid-Lowering Treatment to Prevent Heart Attack T. Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin vs usual care: The antihypertensive and lipid-lowering treatment to prevent heart attack trial (allhat-llt). JAMA 2002; 288: 2998-3007.
[186]
Asselbergs FW, Diercks GF, Hillege HL, et al. Effects of fosinopril and pravastatin on cardiovascular events in subjects with microalbuminuria. Circulation 2004; 110: 2809-16.
[187]
Ridker PM, Danielson E, Fonseca FA, et al. Rosuvastatin to prevent vascular events in men and women with elevated c-reactive protein. N Engl J Med 2008; 359: 2195-207.
[188]
Crouse JR 3rd, Raichlen JS, Riley WA, et al. Effect of rosuvastatin on progression of carotid intima-media thickness in low-risk individuals with subclinical atherosclerosis: The meteor trial. JAMA 2007; 297: 1344-53.

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