Current Pediatric Reviews

Giuseppe Buonocore
Department of Molecular and Developmental Medicine
University of Siena
Siena
Italy

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New Insights into the Surgical Management of Tetralogy of Fallot: Physiological Fundamentals and Clinical Relevance

Author(s): Thierry Bove, Katrien Francois, Daniel De Wolf.

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Abstract:

The surgical treatment of tetralogy of Fallot can be considered as a success story in the history of congenital heart diseases. Since the early outcome is no longer the main issue, the focus moved to the late sequelae of TOF repair, i.e. the pulmonary insufficiency and the secondary adaptation of the right ventricle. This review provides recent insights into the pathophysiological alterations of the right ventricle in relation to the reconstruction of the right ventricular outflow tract after repair of tetralogy of Fallot. Its clinical relevance is documented by addressing the policy changes regarding the optimal management at the time of surgical repair as well as properly defining criteria and timing for late pulmonary valve implantation.

Keywords: Pulmonary regurgitation, right ventricle physiology, surgery, tetralogy of fallot.

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Article Details

VOLUME: 11
ISSUE: 2
Year: 2015
Page: [72 - 86]
Pages: 15
DOI: 10.2174/1573396311666150702103756
Price: $58